<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.1d1 20130915//EN" "http://jats.nlm.nih.gov/publishing/1.1d1/JATS-journalpublishing1.dtd">
<article xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" article-type="review-article" xml:lang="en">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">SAJP</journal-id>
<journal-title-group>
<journal-title>South African Journal of Physiotherapy</journal-title>
</journal-title-group>
<issn pub-type="ppub">0379-6175</issn>
<issn pub-type="epub">2410-8219</issn>
<publisher>
<publisher-name>AOSIS</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="publisher-id">SAJP-79-1939</article-id>
<article-id pub-id-type="doi">10.4102/sajp.v79i1.1939</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Review Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>A scoping review of prehabilitation interventions for arthroplasty patients</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9546-3854</contrib-id>
<name>
<surname>Pillay-Jayaraman</surname>
<given-names>Prithi</given-names>
</name>
<xref ref-type="aff" rid="AF0001">1</xref>
<xref ref-type="aff" rid="AF0002">2</xref>
<xref ref-type="aff" rid="AF0002">3</xref>
</contrib>
<contrib contrib-type="author">
<contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2934-8687</contrib-id>
<name>
<surname>Chetty</surname>
<given-names>Verusia</given-names>
</name>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
<contrib contrib-type="author">
<contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2306-7681</contrib-id>
<name>
<surname>Maddocks</surname>
<given-names>Stacy</given-names>
</name>
<xref ref-type="aff" rid="AF0002">2</xref>
</contrib>
<aff id="AF0001"><label>1</label>Chris Hani Baragwanath Academic Hospital, Faculty of Health, Gauteng Department of Health, Johannesburg, South Africa</aff>
<aff id="AF0002"><label>2</label>Department of Physiotherapy, Faculty of Health Sciences, University of KwaZulu-Natal, Durban, South Africa</aff>
<aff id="AF0003"><label>3</label>Department of Physiotherapy, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa</aff>
</contrib-group>
<author-notes>
<corresp id="cor1"><bold>Corresponding author:</bold> Prithi Pillay-Jayaraman, <email xlink:href="prithijoy80@gmail.com">prithijoy80@gmail.com</email></corresp>
</author-notes>
<pub-date pub-type="epub"><day>14</day><month>11</month><year>2023</year></pub-date>
<pub-date pub-type="collection"><year>2023</year></pub-date>
<volume>79</volume>
<issue>1</issue>
<elocation-id>1939</elocation-id>
<history>
<date date-type="received"><day>03</day><month>07</month><year>2023</year></date>
<date date-type="accepted"><day>12</day><month>09</month><year>2023</year></date>
</history>
<permissions>
<copyright-statement>&#x00A9; 2023. The Authors</copyright-statement>
<copyright-year>2023</copyright-year>
<license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/">
<license-p>Licensee: AOSIS. This work is licensed under the Creative Commons Attribution License.</license-p>
</license>
</permissions>
<abstract>
<sec id="st1">
<title>Background</title>
<p>Osteoarthritis (OA) is a long-term condition that causes significant impairment, and because of the increasing prevalence of OA, the demand for arthroplasty will continue to rise. However, the demand will not be matched by availability, because of prioritisation of trauma-related surgeries. Implementing prehabilitation could assist physiotherapists in having an impact on improving access by reducing the length of stay.</p>
</sec>
<sec id="st2">
<title>Objectives</title>
<p>The aim of our scoping review was to explore, map and identify trends and gaps to better inform the content of a prehabilitation programme.</p>
</sec>
<sec id="st3">
<title>Method</title>
<p>In our scoping review, studies between 1995 and 2020 were identified and included based on inclusion and exclusion criteria and study methodology described by Arksey and O&#x2019;Malley. The results were collated and summarised as a narrative synthesis.</p>
</sec>
<sec id="st4">
<title>Results</title>
<p>A total of 200 articles were identified and exported from four databases of which 48 articles were included in the final analysis. Regarding the efficacy of prehabilitation interventions, 21 studies reported significant results supporting prehabilitation, whereas 11 studies reported non-significant results.</p>
</sec>
<sec id="st5">
<title>Conclusions</title>
<p>Prehabilitation could be a valuable adjunct in reducing length of hospital stay and improving functional outcomes in adults undergoing total joint replacement.</p>
</sec>
<sec id="st6">
<title>Clinical implications</title>
<p>The scoping review described the information available on prehabilitation in lower limb arthroplasty patients and could potentially inform the design of a prehabilitation programme suitable for use in the South African public health context.</p>
</sec>
</abstract>
<kwd-group>
<kwd>prehabilitation</kwd>
<kwd>arthroplasty</kwd>
<kwd>exercise</kwd>
<kwd>rehabilitation</kwd>
<kwd>lower limb</kwd>
<kwd>program design</kwd>
</kwd-group>
<funding-group>
<award-group>
<funding-source>The University of KwaZulu-Natal, South Africa</funding-source>
</award-group>
</funding-group>
</article-meta>
</front>
<body>
<sec id="s0001">
<title>Background</title>
<p>Osteoarthritis (OA) is a long-term condition that causes significant impairment of physical function in individuals. Globally, prevalent cases of OA increased by 113.25&#x0025;, from 247.51 million in 1990 to 527.81 million in 2019 (Long et al. <xref ref-type="bibr" rid="CIT0039">2022</xref>). The highest numbers of prevalent cases in 2019 were observed in China (132.81 million), followed by India (62.36 million) and the United States (51.87 million), with corresponding percentage changes from 1990 to 2019 of 156.58&#x0025;, 165.75&#x0025; and 79.63&#x0025;, respectively (Long et al. <xref ref-type="bibr" rid="CIT0039">2022</xref>). Osteoarthritis presents a burden on individuals, health systems and social care systems, with further indirect cost implications (Woolf &#x0026; Pfleger <xref ref-type="bibr" rid="CIT0074">2003</xref>), and in most cases, OA has clear predisposing risk factors, such as genetics, trauma, ageing or obesity (He et al. <xref ref-type="bibr" rid="CIT0028">2020</xref>). Studies from the United States report that OA affects approximately 10&#x0025; of non-institutionalised adults, resulting in substantial clinical, humanistic and economic burdens (Zhao et al. <xref ref-type="bibr" rid="CIT0076">2019</xref>). A study based in Canada reports that from 2010 to 2031, the prevalence of OA was estimated to increase from 13.8&#x0025; to 18.6&#x0025;, with an almost 2.6-fold cost increase in the management of these patients (Sharif et al. <xref ref-type="bibr" rid="CIT0058">2015</xref>). In terms of the cost components that will constitute the total direct cost of OA in 2031 are hospitalisation cost, outpatient services, alternative care and out-of-pocket cost categories, drugs, rehabilitation and side effects of drugs (Sharif et al. <xref ref-type="bibr" rid="CIT0058">2015</xref>).</p>
<p>The 2017 Global Burden of Disease report ranked hip and knee OA as the 11th-highest contributor to global disability and the 23rd-highest cause of disability-adjusted life years. A study done to investigate the burden of OA in the Middle East and North Africa (MENA) reported that there was an increase in the burden of OA from 1990 to 2019 in the MENA region with a reported increase in the incidence of OA by 9.4&#x0025; from 1990 to 2019 (Shamekh et al. <xref ref-type="bibr" rid="CIT0057">2022</xref>). The study emphasises the importance of early preventative approaches to control any future health, economic and quality of life crises imposed by OA in this region (Shamekh et al. <xref ref-type="bibr" rid="CIT0057">2022</xref>).</p>
<p>The effect of arthritis in higher income countries is reduced workplace productivity; however, in low- and middle-income countries (LMICs), arthritis imposes a potential additional burden by creating a vicious cycle that subsequently worsens poverty (Brennan-Olsen et al. <xref ref-type="bibr" rid="CIT0008">2017</xref>). And yet it is reported that LMICs have 90&#x0025; of the global burden of disease but only 12&#x0025; of global health spending (Brennan-Olsen et al. <xref ref-type="bibr" rid="CIT0008">2017</xref>). The situation is similar in the South African public health sector, which spends 4.5&#x0025; of its gross domestic product on health and serves 86&#x0025; of the population (Motsoaledi <xref ref-type="bibr" rid="CIT0045">2018</xref>), which worsens the impact of arthritis. In South Africa, of all the types of arthritis, OA is the most prevalent with a prevalence of 55.1&#x0025; (95&#x0025; confidence interval [CI]: 40.74&#x2013;73.54) among adults aged 65 years and older in an urban setting; with knee OA prevalence of 33.1&#x0025; (95&#x0025; CI: 27.70&#x2013;38.50) among adults aged 35 years and older in a rural setting (Usenbo et al. <xref ref-type="bibr" rid="CIT0067">2015</xref>). However, there is a paucity of data later than 2015 in South Africa.</p>
<p>Because of ageing populations, the obesity epidemic and an increasing prevalence of OA, the demand for total hip arthroplasty (THA) and total knee arthroplasty (TKA) as a treatment of choice for OA will continue to increase (Kurtz et al. <xref ref-type="bibr" rid="CIT0034">2009</xref>). A recent study conducted in the United States forecasts an increase in the demand for THA procedures to be 176&#x0025; by 2040 and 659&#x0025; by 2060 and the increase for TKA to be 139&#x0025; by 2040 and 469&#x0025; by 2060 (Shichman et al. <xref ref-type="bibr" rid="CIT0060">2023</xref>). Despite the lack of South African-based studies forecasting the future need for arthroplasty, from the global trends, one may anticipate that the need will similarly increase in the South African public and private sectors. The popularity and demand for replacement arthroplasties is due to its success rates and excellent outcomes, achieved with THA surgeries, specifically, being referred to as the &#x2018;operation of the century&#x2019; (Learmonth, Young &#x0026; Rorabeck <xref ref-type="bibr" rid="CIT0036">2007</xref>).</p>
<p>However, in LMICs like South Africa, because of political prioritisation, the peremptory nature of emergency care, trauma and infective pathology, trauma caseloads dominate the workload of the public sector, which serves the majority of the population, and elective procedures like replacement arthroplasty take a back seat and are not prioritised, resulting in the long waiting lists for the procedure (Abera Abaerei, Ncayiyana &#x0026; Levin <xref ref-type="bibr" rid="CIT0001">2017</xref>). In a South African-based study of surgical procedures, 54.2&#x0025; were emergency surgeries with a risk of admission to critical care and 23.7&#x0025; were leading to the conclusion that most patients in South Africa&#x2019;s public sector hospitals undergo urgent and emergency surgery (Biccard &#x0026; Madiba <xref ref-type="bibr" rid="CIT0007">2015</xref>).</p>
<p>The quiet suffering of the functionally impaired patient with arthritis is largely not significant for immediate intervention, based on the assumption that leaving patients with degenerative joint diseases like arthritis to deteriorate and living with pain is less important that other prioritised healthcare needs like emergency work (Dunn <xref ref-type="bibr" rid="CIT0022">2012</xref>). Because of the discrepancies between demand and available resources in the public health sphere in South Africa, patients wait years for arthroplasty procedures. According to the waiting list registry of the arthroplasty unit at the public sector Chris Hani Baragwanath Academic Hospital, a patient assessed as needing an arthroplasty in 2020 could potentially only receive the surgery in 2023 (Dunn <xref ref-type="bibr" rid="CIT0022">2012</xref>; Kavalieratos, Nortje &#x0026; Dunn <xref ref-type="bibr" rid="CIT0031">2017</xref>). The estimated expenditure of uncomplicated hip arthroplasty in a tertiary public hospital in South Africa is ZAR74 185.25 with a minimum and maximum of ZAR60 414.04 and ZAR110 598.62, respectively (Sekeitto &#x0026; Aden <xref ref-type="bibr" rid="CIT0056">2021</xref>), which implies that arthroplasty surgery makes a significant dent in the health expenditure budget. There is a paucity of further academic data regarding cost of knee replacement, complicated surgeries and costing of all cost-driven procedures within the orthopaedic field (Sekeitto &#x0026; Aden <xref ref-type="bibr" rid="CIT0056">2021</xref>).</p>
<p>Patients waiting for elective surgery in the United Kingdom report a significant impact on their health status and quality of life, with 71.2&#x0025; reporting a further deterioration in their condition while waiting and 6.3&#x0025; evaluating their health status as &#x2018;worse than death&#x2019; (Morris et al. <xref ref-type="bibr" rid="CIT0044">2020</xref>). This necessitates consideration of all measures to improve access as an urgent imperative, especially in the face of the recent coronavirus-19 (COVID-19) pandemic, which resulted in waiting lists for elective surgeries becoming even longer (Morris et al. <xref ref-type="bibr" rid="CIT0044">2020</xref>).</p>
<p>One of the ways in which a physiotherapist can assist in improving access to arthroplasty surgery is by implementing measures to decrease the postoperative length of hospital stay, which also has an impact on reducing costs. A broad overview of systematic reviews, and meta-analysis, allowed for the conclusion that some of the studies support the practice of prehabilitation programmes because of their effect on pain, range of motion, physical function, quality of life, length of hospital stay and postoperative outcomes in individuals awaiting joint replacement (Gill &#x0026; McBurney <xref ref-type="bibr" rid="CIT0025">2013</xref>; Moyer et al. <xref ref-type="bibr" rid="CIT0046">2017</xref>; Vasta et al. <xref ref-type="bibr" rid="CIT0068">2020</xref>; Wallis &#x0026; Taylor <xref ref-type="bibr" rid="CIT0070">2011</xref>). However, other studies conclude that prehabilitation programmes not effective in improving outcomes (Almeida, Khoja &#x0026; Zelle <xref ref-type="bibr" rid="CIT0003">2020</xref>; Barbay <xref ref-type="bibr" rid="CIT0005">2009</xref>; Chen et al. <xref ref-type="bibr" rid="CIT0013">2018</xref>; Peer et al. <xref ref-type="bibr" rid="CIT0049">2017</xref>) suggest the need for a thorough exploration of individual studies and a descriptive narrative of the literature to draw a more informed conclusion on the topic. Preoperative optimisation with a multidisciplinary team has been suggested as a need in South Africa with the specific aim to ensure patients are physiologically and mentally fit for surgery (Plenge et al. <xref ref-type="bibr" rid="CIT0051">2020</xref>). The study recommended that the preoperative period be a &#x2018;window of opportunity&#x2019; in a South African setting with low literacy levels and limited ability to seek information. A pragmatic approach to patient education would improve patient empowerment and participation in postoperative rehabilitation (Plenge et al. <xref ref-type="bibr" rid="CIT0051">2020</xref>). The long waiting period gives credence to this rationale.</p>
<p>The preliminary review of the literature allowed for the identification of gaps in prehabilitation programmes, including limitations regarding the types of exercises prescribed, with specific reference to the exclusion of foot exercises, balance and proprioceptive exercises, despite anecdotal and clinical observations of the presence of foot deformities, like flat feet and hallux valgus (HV). In terms of the content of the education provided in a South African setting, the overview of the literature highlights a lack of pain neuroscience education (Saw et al. <xref ref-type="bibr" rid="CIT0055">2016</xref>). A detailed synthesis of the literature will inform other aspects of prehabilitation programmes, such as the minimum number of sessions needed for clinically significant results, the mode of delivery and the potential need for intensive face-to-face sessions weeks prior to the surgery. In the context of a resource-constrained country like South Africa, there is a need for delivering effective prehabilitation programmes as transport cost and time spent waiting in hospitals have an impact on patients accessing hospital services (Abera Abaerei et al. <xref ref-type="bibr" rid="CIT0001">2017</xref>). The principles enshrined in the Batho Pele concepts of healthcare delivery dictate that value for money be an important consideration for healthcare professionals when delivering services (James &#x0026; Miza <xref ref-type="bibr" rid="CIT0030">2015</xref>). Our scoping review may also inform and strengthen the formulation of a standard package of care for arthroplasty patients in public hospitals in South Africa, prompting the need for all relevant literature to be exhaustively analysed, critiqued and described, prior to constructing the framework of the prehabilitation programme.</p>
</sec>
<sec id="s0002">
<title>Methodology</title>
<p>The protocol for our scoping review has been registered within the Open Science Framework platform (<ext-link ext-link-type="uri" xlink:href="https://osf.io/9fdsh/">https://osf.io/9fdsh/</ext-link>), and our study protocol is being reported in accordance with the reporting guidance provided in the PRISMA extension for scoping reviews (PRISMA-ScR) (Online Appendix 1). The scoping review methodology, steps in defining the research question and selection of eligible studies have been described extensively in a previously published paper by the same authors (Pillay-Jayaraman, Maddocks &#x0026; Chetty <xref ref-type="bibr" rid="CIT0050">2023</xref>).</p>
<p>In the search for literature, computer databases like Google Scholar, Pubmed, Ebsco and Cochrane Library were used, and any studies conducted between 1995 and 2020 were included in the search. The Boolean terms &#x2018;AND&#x2019;, &#x2018;OR&#x2019; and &#x2018;NOT&#x2019; were used to separate keywords. Search terms included were knee, hip, joint replacement; arthroplasty; physiotherapy; physical therapy; exercise; rehabilitation and prehabilitation. To synthesise the principles of exercise prescription from the literature, and to better inform the construction of a prehabilitation programme, those papers that elaborated and described aspects of exercises, prescribing aerobic, anaerobic, strengthening, flexibility, resistance, balance and functional activities, were included. The studies were also scrutinised for the principles of exercise prescription in terms of the frequency, intensity, time and type (FITT) and their correlation to efficacy and outcomes of treatment. Papers with content on education as a preparation, either as the sole model for prehabilitation or as an adjunct for joint arthroplasty optimisation, were also included.</p>
<p>The above principles formed the basis for article selection and the databases that were searched and articles identified from each have been represented in <xref ref-type="fig" rid="F0001">Figure 1</xref>. Duplicate records were removed by automation tools such as EndNote (<italic>n</italic> = 65) before screening. The three reviewers who were familiar with the study protocol were involved in the scoping review process. Title, abstract and keywords screening of all eligible articles were conducted by the first author (P.P.) and second reviewer (H.E.). Excluded citations were reviewed and confirmed by a third reviewer (V.C.). The next step was to obtain full texts of all the selected articles by undertaking a thorough and exhaustive search of the web. In those instances where the full text could not be obtained from the web, a concerted effort was made to obtain these full-text articles by engaging with the university subject librarian and/or contacting the author(s) as necessary. Full-text screening to ascertain whether the selected articles met the inclusion criteria was conducted by all reviewers (P.P., H.E. and V.C.) independently. Major discrepancies and lack of agreement among reviewers (P.P. and H.E.) for inclusion in the scoping review were resolved through discussion.</p>
<fig id="F0001">
<label>FIGURE 1</label>
<caption><p>PRISMA flowchart of identification of studies via databases.</p></caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="SAJP-79-1939-g001.tif"/>
</fig>
<p>Data from the studies were charted according to the information from randomised controlled trials and descriptive studies (Online Appendix 2) to gather as much detailed information as possible on the metrics used to describe prehabilitation in arthroplasty and to describe the interventions in detail to inform the development of a prehabilitation programme.</p>
<sec id="s20003">
<title>Ethical considerations</title>
<p>This article does not contain any studies involving human participants performed by any of the authors.</p>
</sec>
</sec>
<sec id="s0004">
<title>Results</title>
<p>A total of 200 articles were identified and exported to EndNote version 20.5. After the review of titles, and removal of duplicates, 103 articles were selected. Title and abstract screening resulted in 48 articles being included, while 55 articles were excluded, for reasons including that the articles were protocols, theses or commentary pieces, and had the wrong population or outcomes. Full-text articles were then retrieved and a final 48 articles were collated and charted to answer the research question at hand (<xref ref-type="fig" rid="F0001">Figure 1</xref>).</p>
</sec>
<sec id="s0005">
<title>Description of studies: Systematic reviews and meta-analyses</title>
<p>The literature search revealed that there were 8 systematic reviews and 6 meta-analyses, with 3 papers on total knee replacement and 11 on joint replacement. Six of the studies reported improvements in length of hospital stay (Almeida et al. <xref ref-type="bibr" rid="CIT0003">2020</xref>; Chen et al. <xref ref-type="bibr" rid="CIT0013">2018</xref>; Coudeyre et al. <xref ref-type="bibr" rid="CIT0015">2007</xref>; Moyer et al. <xref ref-type="bibr" rid="CIT0046">2017</xref>; Sharma, Ardebili &#x0026; Abdulla <xref ref-type="bibr" rid="CIT0059">2019</xref>; Vasta et al. <xref ref-type="bibr" rid="CIT0068">2020</xref>), and two reported no improvement (Kwok, Paton &#x0026; Haddad <xref ref-type="bibr" rid="CIT0035">2015</xref>; Wang et al. <xref ref-type="bibr" rid="CIT0072">2006</xref>). Of the systematic reviews that looked at functional outcomes, four studies reported no improvement in functional outcomes (Ackerman &#x0026; Bennell <xref ref-type="bibr" rid="CIT0002">2004</xref>; Almeida et al. <xref ref-type="bibr" rid="CIT0003">2020</xref>; Kwok et al. <xref ref-type="bibr" rid="CIT0035">2015</xref>; Sharma et al. <xref ref-type="bibr" rid="CIT0059">2019</xref>); four reported improvements in outcomes (Chen et al. <xref ref-type="bibr" rid="CIT0013">2018</xref>; Moyer et al. <xref ref-type="bibr" rid="CIT0046">2017</xref>; Vasta et al. <xref ref-type="bibr" rid="CIT0068">2020</xref>; Wang et al. <xref ref-type="bibr" rid="CIT0072">2006</xref>); two reported improvements in pain (Gill &#x0026; McBurney <xref ref-type="bibr" rid="CIT0025">2013</xref>; Wang et al. <xref ref-type="bibr" rid="CIT0072">2006</xref>); one reported improvements on postoperative recovery (Wang et al. <xref ref-type="bibr" rid="CIT0072">2006</xref>) and one study reported no improvement in isometric quadriceps muscle strength (Peer et al. <xref ref-type="bibr" rid="CIT0049">2017</xref>). The majority of the studies reported positive results in length of hospital stay, outcomes, pain, strength and functional recovery, following hip replacement. In terms of the results for knee replacement, one study found prehabilitation to be effective in reducing length of hospital stay (Chen et al. <xref ref-type="bibr" rid="CIT0013">2018</xref>) but two studies reported no effect of prehabilitation on quadriceps strength (Chen et al. <xref ref-type="bibr" rid="CIT0013">2018</xref>; Peer et al. <xref ref-type="bibr" rid="CIT0049">2017</xref>) and one study concluded that there was no added advantage of prehabilitation (Ma et al. <xref ref-type="bibr" rid="CIT0040">2018</xref>).</p>
<p>The results were not conclusive because of the randomised controlled trials not being well designed (Ma et al. <xref ref-type="bibr" rid="CIT0040">2018</xref>). There was no standardisation in the prehabilitation programmes, with variation in the prehabilitation protocols (Almeida et al. <xref ref-type="bibr" rid="CIT0003">2020</xref>; Chen et al. <xref ref-type="bibr" rid="CIT0013">2018</xref>; Gill &#x0026; McBurney <xref ref-type="bibr" rid="CIT0025">2013</xref>). The studies had small sample size and a power analysis was not reported in most of the papers included in the study by Vasta et al. (<xref ref-type="bibr" rid="CIT0068">2020</xref>). It was reported that the small sample size could lead to an unpredictable overestimation or underestimation of the results (Vasta et al. <xref ref-type="bibr" rid="CIT0068">2020</xref>). Recommendations stemming from the analysis of systematic reviews and the meta-analysis were that more research was needed to emphatically conclude on the effects of prehabilitation (Barbay <xref ref-type="bibr" rid="CIT0005">2009</xref>; Wallis &#x0026; Taylor <xref ref-type="bibr" rid="CIT0070">2011</xref>). It is essential to develop and describe a comprehensive prehabilitation programme (Almeida et al. <xref ref-type="bibr" rid="CIT0003">2020</xref>) and assess the effectiveness of pre- and post-intervention when compiling and reporting on the effects of prehabilitation (Almeida et al. <xref ref-type="bibr" rid="CIT0003">2020</xref>). In addition, training intensity (Chen et al. <xref ref-type="bibr" rid="CIT0013">2018</xref>), appropriate dosage (Kwok et al. <xref ref-type="bibr" rid="CIT0035">2015</xref>) and compliance with therapy need to be reported to ensure desired outcomes of therapy are achieved (Wang et al. <xref ref-type="bibr" rid="CIT0071">2016</xref>). The studies also recommend that an intervention 6 weeks before the surgery may not yield sufficient, statistically significant, clinical gains (Kwok et al. <xref ref-type="bibr" rid="CIT0035">2015</xref>), and adherence may be affected by the need to travel frequently a few weeks prior to the surgery to attend face-to-face therapy. Hence, consideration of these factors may lead to a different picture and more conclusive answers. Another factor that is relevant in the context of a country like South Africa based on the limited research on the topic is that patients with knee arthritis had waited on average 461 (90&#x2013;1513 [222.8]) days and hip replacements waited on average of 412 (104&#x2013;1593 [242.3]) days (Kavalieratos et al. <xref ref-type="bibr" rid="CIT0031">2017</xref>). While this presents many challenges, it does on the other hand present the opportunity to have more time to optimise patients. In addition, patient&#x2019;s experience of care, satisfaction and preparedness should also be considered in assessing effectiveness.</p>
<p><xref ref-type="table" rid="T0001">Table 1</xref> is a description of study characteristics of randomised controlled trials and descriptive studies.</p>
<table-wrap id="T0001">
<label>TABLE 1</label>
<caption><p>Study characteristics of randomised controlled trials and descriptive studies (Online Appendix 2, Table 3).</p></caption>
<table frame="hsides" rules="groups">
<thead>
<tr>
<th valign="top" align="left">Methodology types</th>
<th valign="top" align="left">Sample size</th>
<th valign="top" align="left">Study duration</th>
<th valign="top" align="left">Compliance</th>
<th valign="top" align="left">Mode of delivery</th>
<th valign="top" align="left">Results</th>
</tr>
</thead>
<tbody>
<tr>
<td align="left">RCT: 23<break/><break/>Prospective: 3<break/><break/>Retrospective: 3<break/><break/>Other: 5 (case studies, longitudinal cohorts, descriptive cross-sectional surveys observational cohorts)</td>
<td align="left">Average: 110.6<break/><break/>Minimum: Case study (Ehrlich <xref ref-type="bibr" rid="CIT0023">2019</xref>): 1 <break/><break/>Maximum: Survey design: 608<break/><break/>Mode: 20 and 35 patients</td>
<td align="left">Average: 6.5 weeks <break/><break/>Minimum: 6 weeks <break/><break/>Maximum: 12 weeks<break/><break/>Mode: 8 weeks</td>
<td align="left">Average: 16.6 sessions<break/><break/>Minimum: 6 sessions<break/><break/>Maximum: 60 sessions<break/><break/>Mode: 24 sessions</td>
<td align="left">Home: 4<break/><break/>Face-to-Face: 20 Hybrid: 10</td>
<td align="left">Statistically significant: 21<break/><break/>Not significant: 11</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn><p>Note: Please see the article, Pillay-Jayaraman, P., Chetty, V. &#x0026; Maddocks, S., 2023, &#x2018;A scoping review of prehabilitation interventions for arthroplasty patients&#x2019;, <italic>South African Journal of Physiotherapy</italic> 79(1), a1939. <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.4102/sajp.v79i1.1939">https://doi.org/10.4102/sajp.v79i1.1939</ext-link>, for more information on where to find Online Appendix 2.</p></fn>
<fn><p>RCT, randomised controlled trial.</p></fn>
</table-wrap-foot>
</table-wrap>
</sec>
<sec id="s0006">
<title>Description of exercise interventions</title>
<p>Twenty-nine studies used exercise-based interventions. However, two studies (Kosek et al. <xref ref-type="bibr" rid="CIT0033">2013</xref>; Topp et al. <xref ref-type="bibr" rid="CIT0066">2009</xref>) did not discuss the intervention in detail and two studies used hydrotherapy (Gill, McBurney &#x0026; Schulz <xref ref-type="bibr" rid="CIT0026">2009</xref>; Sunghye et al. <xref ref-type="bibr" rid="CIT0063">2021</xref>) as a means of delivering exercises. The exercise programmes used could be categorised into isometric, range of motion, aerobic, strengthening, stretching and circuit exercises. Two studies targeted quadriceps for isometric contractions (Aytekin et al. <xref ref-type="bibr" rid="CIT0004">2019</xref>; Cavill et al. <xref ref-type="bibr" rid="CIT0012">2016</xref>) and seven studies incorporated range of motion exercises (Aytekin et al. <xref ref-type="bibr" rid="CIT0004">2019</xref>; Cavill et al. <xref ref-type="bibr" rid="CIT0012">2016</xref>; Desmeules, Hall &#x0026; Woodhouse <xref ref-type="bibr" rid="CIT0018">2013</xref>; Doiron-Cadrin et al. <xref ref-type="bibr" rid="CIT0019">2020</xref>; Gill et al. <xref ref-type="bibr" rid="CIT0026">2009</xref>; Rooks et al. <xref ref-type="bibr" rid="CIT0054">2006</xref>; Sunghye et al. <xref ref-type="bibr" rid="CIT0063">2021</xref>). The most common joints targeted were the hip, knee and ankle, whereas the study by Rooks et al. (<xref ref-type="bibr" rid="CIT0054">2006</xref>) incorporated single planar motion of the cervical spine, shoulders, elbows, wrists and hands (Rooks et al. <xref ref-type="bibr" rid="CIT0054">2006</xref>). Aerobic exercises were described in 13 studies and included a warm-up session (Brown et al. <xref ref-type="bibr" rid="CIT0010">2012</xref>; D&#x2019;Lima et al. <xref ref-type="bibr" rid="CIT0016">1996</xref>; Doiron-Cadrin et al. <xref ref-type="bibr" rid="CIT0019">2020</xref>) of walking (Kim et al. <xref ref-type="bibr" rid="CIT0032">2020</xref>; McKay, Prapavessis &#x0026; Doherty <xref ref-type="bibr" rid="CIT0041">2012</xref>; Swank et al. <xref ref-type="bibr" rid="CIT0064">2011</xref>) or used equipment like a stationary bike (Cavill et al. <xref ref-type="bibr" rid="CIT0012">2016</xref>; Desmeules et al. <xref ref-type="bibr" rid="CIT0018">2013</xref>; Gill et al. <xref ref-type="bibr" rid="CIT0026">2009</xref>; McKay et al. <xref ref-type="bibr" rid="CIT0041">2012</xref>; Moe &#x0026; Dagfinrud <xref ref-type="bibr" rid="CIT0043">2014</xref>; Rooks et al. <xref ref-type="bibr" rid="CIT0054">2006</xref>; Villadsen et al. <xref ref-type="bibr" rid="CIT0069">2014</xref>) or arm ergometry (Calatayud et al. <xref ref-type="bibr" rid="CIT0011">2017</xref>). The main reason behind incorporating an aerobic session was to improve cardiovascular conditioning, maintain heart rate and improve general fitness (D&#x2019;Lima et al. <xref ref-type="bibr" rid="CIT0016">1996</xref>; Kim et al. <xref ref-type="bibr" rid="CIT0032">2020</xref>). The majority of the studies did aerobic exercises for 10 min, increasing to a maximum time of 20 min (Kim et al. <xref ref-type="bibr" rid="CIT0032">2020</xref>).</p>
<p>Strengthening exercises were most frequently used, with 22 studies describing them as part of the prehabilitation programme regime. Muscles targeted for strengthening predominately included the abdominals and lower limb muscles like triceps surae, quadriceps, hamstrings, hip flexors, hip extensors, hip abductors and the calf muscles. In the study by Rooks et al. (<xref ref-type="bibr" rid="CIT0054">2006</xref>), upper limb muscles like shoulder flexors, shoulder abductors and triceps brachii were also strengthened.</p>
<p>Stretching was used in 15 of the papers. In this context, the term &#x2018;stretching&#x2019; was an umbrella term that included flexibility exercises and a way of cooling down. The stretching or cooling down was done for a minimum of 5 min (Calatayud et al. <xref ref-type="bibr" rid="CIT0011">2017</xref>) and a maximum of 15 min (Brown et al. <xref ref-type="bibr" rid="CIT0010">2012</xref>, <xref ref-type="bibr" rid="CIT0009">2014</xref>), with 2&#x2013;3 repetitions held for 20 s &#x2013; 30 s. Step training was another intervention utilised which included going up and down a single step, forward and then sideways to the left and right, and starting from a step height of 2 inches &#x2013; 3 inches (5 cm &#x2013; 7 cm), going up to 4 inches &#x2013; 7 inches (Brown et al. <xref ref-type="bibr" rid="CIT0009">2014</xref>; Cavill et al. <xref ref-type="bibr" rid="CIT0012">2016</xref>; Swank et al. <xref ref-type="bibr" rid="CIT0064">2011</xref>). Other exercises included functional weight-bearing exercises which imitated functions of daily living and taught patients how to control hip-knee-foot alignment (Fernandes et al. <xref ref-type="bibr" rid="CIT0024">2017</xref>).</p>
<p>Circuit training was also used as an approach for preoperative optimisation in six studies (Clode, Perry &#x0026; Wulff <xref ref-type="bibr" rid="CIT0014">2018</xref>; Huber et al. <xref ref-type="bibr" rid="CIT0029">2015</xref>; McKay et al. <xref ref-type="bibr" rid="CIT0041">2012</xref>; Moe &#x0026; Dagfinrud <xref ref-type="bibr" rid="CIT0043">2014</xref>; Swank et al. <xref ref-type="bibr" rid="CIT0064">2011</xref>; Villadsen et al. <xref ref-type="bibr" rid="CIT0069">2014</xref>), using 4 (Huber et al. <xref ref-type="bibr" rid="CIT0029">2015</xref>) to 13 exercises (Clode et al. <xref ref-type="bibr" rid="CIT0014">2018</xref>). The main purpose was to improve core stability or postural function and orientation, functional alignment, lower extremity and muscle strength. Studies also used manual therapy, such as patellofemoral joint mobilisation (Cavill et al. <xref ref-type="bibr" rid="CIT0012">2016</xref>); balance (static and dynamic) (Denduluri, Huddleston &#x0026; Amanatullah <xref ref-type="bibr" rid="CIT0017">2020</xref>), without and with a balance trainer (Calatayud et al. <xref ref-type="bibr" rid="CIT0011">2017</xref>); and proprioceptive exercises (Doiron-Cadrin et al. <xref ref-type="bibr" rid="CIT0019">2020</xref>). Relaxation and visualisation (Saw et al. <xref ref-type="bibr" rid="CIT0055">2016</xref>), ice pack (Beaupre et al. <xref ref-type="bibr" rid="CIT0006">2004</xref>) and transcutaneous electric nerve stimulation (Rahmatika, Novriansyah &#x0026; Indriastuti <xref ref-type="bibr" rid="CIT0052">2020</xref>) and practicing with gait aids (Desmeules et al. <xref ref-type="bibr" rid="CIT0018">2013</xref>) were other techniques incorporated.</p>
<p>Compliance was noted by attendance and keeping exercise logs (Online Appendix 2, Table 3), and in the study by Saw et al. (<xref ref-type="bibr" rid="CIT0055">2016</xref>), participants were required to set exercise and activity goals on a weekly basis and to record these in their workbooks (Saw et al. <xref ref-type="bibr" rid="CIT0055">2016</xref>). In the study by D&#x2019;Lima et al. (<xref ref-type="bibr" rid="CIT0016">1996</xref>), patients were taught to use a graphed exercise programme to meet a goal determined by the patient and physiotherapist, based on the patient&#x2019;s capabilities. The graph was used to record the number of repetitions, which was increased by one repetition every third day until the goal was reached (D&#x2019;Lima et al. <xref ref-type="bibr" rid="CIT0016">1996</xref>).</p>
</sec>
<sec id="s0007">
<title>Description of educational interventions</title>
<p>A total of 12 studies described educational interventions as a part of the prehabilitation programme. The overarching themes in the content of preoperative education were analysed. The main themes included preoperative preparation, hospital information, discharge information, postoperative management, patients&#x2019; expectations, precautions and contraindications, transfers, ambulation and assistive devices, the home environment, goal setting, surgery information and OA information.</p>
<p>There were four studies that included preoperative preparation as a part of the content and discussed with patients on how to prepare for surgery (Lewis et al. <xref ref-type="bibr" rid="CIT0038">2020</xref>; Rooks et al. <xref ref-type="bibr" rid="CIT0054">2006</xref>; Soeters et al. <xref ref-type="bibr" rid="CIT0062">2018</xref>; Tait, Dredge &#x0026; Barnes <xref ref-type="bibr" rid="CIT0065">2015</xref>). In five studies, hospital information was included as a part of the content and informed patients on what to expect day one post-surgery, things to bring for the hospital stay and examples of exercises that would be prescribed after the surgery (Denduluri et al. <xref ref-type="bibr" rid="CIT0017">2020</xref>; Lewis et al. <xref ref-type="bibr" rid="CIT0038">2020</xref>; Rooks et al. <xref ref-type="bibr" rid="CIT0054">2006</xref>; Soeters et al. <xref ref-type="bibr" rid="CIT0062">2018</xref>; Tait et al. <xref ref-type="bibr" rid="CIT0065">2015</xref>). Five studies included discharge information as part of the content and elaborated on discharge destination and guidelines (Clode et al. <xref ref-type="bibr" rid="CIT0014">2018</xref>; Denduluri et al. <xref ref-type="bibr" rid="CIT0017">2020</xref>; Lewis et al. <xref ref-type="bibr" rid="CIT0038">2020</xref>; Tait et al. <xref ref-type="bibr" rid="CIT0065">2015</xref>). In six studies, postoperative management information such as information on postoperative pain management, details of postoperative rehabilitation, the postoperative range-of-motion routine and physiotherapist recommendations for recovery were discussed with patients (Denduluri et al. <xref ref-type="bibr" rid="CIT0017">2020</xref>; Huber et al. <xref ref-type="bibr" rid="CIT0029">2015</xref>; Soeters et al. <xref ref-type="bibr" rid="CIT0062">2018</xref>; Tait et al. <xref ref-type="bibr" rid="CIT0065">2015</xref>; Villadsen et al. <xref ref-type="bibr" rid="CIT0069">2014</xref>). The study by Soeters et al. (<xref ref-type="bibr" rid="CIT0062">2018</xref>) was the only study in which patient expectations and goal setting were discussed (Soeters et al. <xref ref-type="bibr" rid="CIT0062">2018</xref>). In three studies, precautions and contraindications (Lewis et al. <xref ref-type="bibr" rid="CIT0038">2020</xref>; Soeters et al. <xref ref-type="bibr" rid="CIT0062">2018</xref>; Tait et al. <xref ref-type="bibr" rid="CIT0065">2015</xref>) were discussed and three studies discussed transfers (Aytekin et al. <xref ref-type="bibr" rid="CIT0004">2019</xref>; Soeters et al. <xref ref-type="bibr" rid="CIT0062">2018</xref>). In addition to education, the patient in one study also had an opportunity to practice transfers in and out of bed, a chair, a toilet seat or a car (Aytekin et al. <xref ref-type="bibr" rid="CIT0004">2019</xref>). Four studies discussed ambulation and assistive devices, where the options for ambulation with and without assistive devices, negotiation of stairs before surgery and crutch walking on ground level and on stairs were discussed (Aytekin et al. <xref ref-type="bibr" rid="CIT0004">2019</xref>; Lewis et al. <xref ref-type="bibr" rid="CIT0038">2020</xref>; Soeters et al. <xref ref-type="bibr" rid="CIT0062">2018</xref>). Six studies discussed home environment modifications with their patients, with specific reference to potential assistive equipment, safety recommendations for the home environment and modifying a home to improve accessibility (Aytekin et al. <xref ref-type="bibr" rid="CIT0004">2019</xref>; Denduluri et al. <xref ref-type="bibr" rid="CIT0017">2020</xref>; Lewis et al. <xref ref-type="bibr" rid="CIT0038">2020</xref>; Rooks et al. <xref ref-type="bibr" rid="CIT0054">2006</xref>; Soeters et al. <xref ref-type="bibr" rid="CIT0062">2018</xref>; Tait et al. <xref ref-type="bibr" rid="CIT0065">2015</xref>). Four studies discussed surgery information with their patients, including the risks of surgery (Aytekin et al. <xref ref-type="bibr" rid="CIT0004">2019</xref>; Denduluri et al. <xref ref-type="bibr" rid="CIT0017">2020</xref>; Tait et al. <xref ref-type="bibr" rid="CIT0065">2015</xref>; Villadsen et al. <xref ref-type="bibr" rid="CIT0069">2014</xref>), and four other studies discussed information regarding OA, the pathogenesis of advanced OA and disability (Aytekin et al. <xref ref-type="bibr" rid="CIT0004">2019</xref>; Clode et al. <xref ref-type="bibr" rid="CIT0014">2018</xref>; Gill et al. <xref ref-type="bibr" rid="CIT0026">2009</xref>; Saw et al. <xref ref-type="bibr" rid="CIT0055">2016</xref>).</p>
</sec>
<sec id="s0008">
<title>Discussion</title>
<p>In our review of 4376 participants in 34 randomised and descriptive studies, 21 studies reported that their results were significant, while 11 studies reported non-significant results. Because the majority of the studies reported a significant result, it allows for a conclusion that prehabilitation programmes are indeed a valuable adjunct to treatment, and this is in keeping with the review by Moyer et al. (<xref ref-type="bibr" rid="CIT0046">2017</xref>), which analysed 35 individual studies (2956 subjects) and reported that a prehabilitation programme could improve physical function, quadricep strength, length of hospital stay and pain, after total joint replacement (Moyer et al. <xref ref-type="bibr" rid="CIT0046">2017</xref>). Similar findings were reported by Chen et al. (<xref ref-type="bibr" rid="CIT0013">2018</xref>), and in this systematic review, 16 studies were analysed (966 subjects). The study reported that prehabilitation programmes had the potential to improve physical function, range of motion and length of hospital stay, after total knee replacement (Chen et al. <xref ref-type="bibr" rid="CIT0013">2018</xref>). There were two reviews that focused on length of hospital stay after total knee replacements and both studies reported that prehabilitation programmes had a positive effect, including reducing the length of hospital stay (Ma et al. <xref ref-type="bibr" rid="CIT0040">2018</xref>; Sharma et al. <xref ref-type="bibr" rid="CIT0059">2019</xref>).</p>
<p>The above results are, however, contrary to the finding of the review by Almeida et al. (<xref ref-type="bibr" rid="CIT0003">2020</xref>), whose study concluded that it was unknown if prehabilitation programmes improved functional outcomes, as preoperative functional status had not been established. The review noted that if studies had not assessed the efficacy of prehabilitation programmes preoperatively, then it was not possible to assess the impact of the programme in improving strength and physical function postoperatively (Almeida et al. <xref ref-type="bibr" rid="CIT0003">2020</xref>). In our review, 33 studies were intervention-based studies and the majority (18) of those studies evaluated the efficacy of prehabilitation by assessing outcomes prior to the surgery. However, only 10 of the studies reported significant results at the end of the assessment period. The review by Almeida et al. (<xref ref-type="bibr" rid="CIT0003">2020</xref>) also reported that none of the systematic reviews assessed compliance with the rehabilitation programme, unlike in the findings of our review, where compliance was recorded and reported in 21 studies (Almeida et al. <xref ref-type="bibr" rid="CIT0003">2020</xref>).</p>
<p>There was only one South African-based study (74 participants) in our review and the primary outcome focused on pain, measured by the brief pain inventory and an open-ended questionnaire assessing the patient&#x2019;s experience (Saw et al. <xref ref-type="bibr" rid="CIT0055">2016</xref>). The results of the study showed that the intervention group had significant improvements compared to the control group, with moderate-to-large effect sizes (ES) on pain severity, and 53&#x0025; of participants reported that the intervention decreased their pain. The study recommended that further research be conducted to explore long-term and postoperative outcomes (Saw et al. <xref ref-type="bibr" rid="CIT0055">2016</xref>). This was the only study that had a targeted intervention for the pain experienced with OA. It is understood and described in the literature that the pain experienced by patients with OA is a complex, subjective phenomenon, where each individual&#x2019;s experience is unique and influenced by biological, psychological and social factors (Neogi <xref ref-type="bibr" rid="CIT0047">2013</xref>). Hence, pain neuroscience education and addressing the multifaceted nature of the pain experience should form an important part of any prehabilitation programme in order to have the desired positive outcome of the surgery.</p>
<p>The most utilised intervention to improve outcomes was the use of strengthening exercises. However, from anecdotal experience and the profile of the patients accessing the arthroplasty services in the public sector, the inclusion of balance and proprioception exercises is an important component of a comprehensive prehabilitation programme. Two studies incorporated balance exercises as part of their programme (Calatayud et al. <xref ref-type="bibr" rid="CIT0011">2017</xref>; Denduluri et al. <xref ref-type="bibr" rid="CIT0017">2020</xref>). The study by Denduluri et al. (<xref ref-type="bibr" rid="CIT0017">2020</xref>) did not elaborate on the exact nature of the exercises; and in the study by Calatayud et al. (<xref ref-type="bibr" rid="CIT0011">2017</xref>), participants performed four sets of 30 s double leg stance exercises and four sets of 15 s of single leg stance exercises on the same unstable device (Bosu<sup>&#x00AE;</sup> Balance Trainer), starting with the non-affected leg. Proprioceptive exercises were included in two studies, but these studies did not describe the exercises in detail (Desmeules et al. <xref ref-type="bibr" rid="CIT0018">2013</xref>; Doiron-Cadrin et al. <xref ref-type="bibr" rid="CIT0019">2020</xref>). No studies specifically evaluated the efficacy of balance and proprioceptive exercises. However, a meta-analysis by Zhang and Xiao (<xref ref-type="bibr" rid="CIT0075">2020</xref>) suggested that, in patients&#x2019; post-arthroplasty, balance and proprioceptive training after total joint arthroplasty improved self-reported functionality and balance, which were maintained mid-term (Zhang &#x0026; Xiao <xref ref-type="bibr" rid="CIT0075">2020</xref>). In another synthesis, Dom&#x00ED;nguez-Navarro et al. (<xref ref-type="bibr" rid="CIT0020">2018</xref>) concluded that, in clinical terms, balance training was a convenient adjunct to conventional physiotherapy care to improve balance and functionality after a knee replacement (Dom&#x00ED;nguez-Navarro et al. <xref ref-type="bibr" rid="CIT0020">2018</xref>). The inclusion of balance and proprioceptive exercises has also been studied in patients with OA, and the study by Duman et al. (<xref ref-type="bibr" rid="CIT0021">2012</xref>) recommended that adding exercises specifically targeting the proprioceptive and balance dysfunction is beneficial for patients with advanced OA (Duman et al. <xref ref-type="bibr" rid="CIT0021">2012</xref>). In the systematic review by Smith, King and Hing (<xref ref-type="bibr" rid="CIT0061">2012</xref>), it was concluded that there is some evidence to indicate the efficacy of proprioceptive exercises, compared to general strengthening exercises, in functional outcomes in patients with OA (Smith et al. <xref ref-type="bibr" rid="CIT0061">2012</xref>). The above indicates a definitive gap in the design of prehabilitation programmes, and that balance and proprioceptive exercises should be included as an integral component when designing a prehabilitation programme.</p>
<p>Balance and proprioception can also be impacted by foot pain and deformities and there has been a definitive link in the literature between these factors and OA. Prevalence and incidence studies have identified that severe foot pain is more common in obese women, aged 65&#x2013;74 years, with hand or knee OA, who walk more slowly and perform the timed five sit to stand from a chair slower that the cohort average (Leveille et al. <xref ref-type="bibr" rid="CIT0037">1998</xref>). Wilder, Barrett and Farina (<xref ref-type="bibr" rid="CIT0073">2005</xref>) found that, in both genders, there was a significant, positive relationship between grade 2+ foot OA and second distal interphalangeal joint, third proximal interphalangeal joint, first carpometacarpal joint and knee OA. This relationship remained significant after adjustment for age, body mass index (BMI) and occupational history (Wilder et al. <xref ref-type="bibr" rid="CIT0073">2005</xref>). Foot conditions like HV are prevalent in the community and are associated with age, the female sex and components of generalised OA, such as nodal OA, knee pain, big toe pain and self-reported OA. Hallux valgus poses a significant health problem and is associated with foot pain, poor balance, immobility and the risk of falling (Roddy, Zhang &#x0026; Doherty <xref ref-type="bibr" rid="CIT0053">2008</xref>). In a study by Golightly et al. (<xref ref-type="bibr" rid="CIT0027">2015</xref>), HV was associated with the female sex, African Americans, older individuals, pes planus and knee or hip OA. It was inversely associated with higher BMI in this population study (Golightly et al. <xref ref-type="bibr" rid="CIT0027">2015</xref>). In terms of foot problems and their correlation with balance, the study by Menz and Lord (<xref ref-type="bibr" rid="CIT0042">2001</xref>) concluded that foot problems are common in older people and are associated with impaired balance and performance in functional tests. They also concluded that foot problems are a risk factor for falling and suggested that the cumulative effect of multiple foot problems is more important in increasing the risk of falling, than the presence or absence of individual foot conditions (Menz &#x0026; Lord <xref ref-type="bibr" rid="CIT0042">2001</xref>). Similar profiles can be found in the public health population and anecdotal evidence exists to confirm a similar clinical picture in South Africa. Hence, the recommendation that there is a need to fill this gap in the literature by providing targeted interventions that address balance and proprioception is justified. In addition, foot deformities could be addressed by conservative management and the routine inclusion of podiatry for holistic management.</p>
</sec>
<sec id="s0009">
<title>Conclusion and recommendations</title>
<p>Prehabilitation could be a valuable adjunct in reducing the length of hospital stay and improving functional outcomes in adults undergoing total joint replacement. However, future studies must consider chronic pain neuroscience education, balance and proprioceptive training, as integral elements in the prehabilitation programme. In the South African public health context, which serves most of the population, the waiting lists for arthroplasty are extensive and there is certainly a huge need to optimise patients. Considering the economic challenges in communities, a hybrid approach of face-to-face therapy and telerehabilitation will serve to enhance compliance and patient activity, ensuring the successful implementation of the prehabilitation programme. Based on the scoping review, a possible ideal version of the programme is presented in Online Appendix 3. A potential limitation of the scoping review methodology is the fact that only English language papers were considered, notwithstanding further research is needed to determine the impact of language restriction on systematic reviews in particular fields of medicine.</p>
</sec>
</body>
<back>
<ack>
<title>Acknowledgements</title>
<sec id="s20010" sec-type="COI-statement">
<title>Competing interests</title>
<p>The author(s) declare that they have no financial or personal relationship(s) that may have inappropriately influenced them in writing this article.</p>
</sec>
<sec id="s20011">
<title>Authors&#x2019; contributions</title>
<p>P.P-J., V.C. and S.M. all contributed equally to this work.</p>
</sec>
<sec id="s20013" sec-type="data-availability">
<title>Data availability</title>
<p>Data sharing is not applicable to this article as no new data were created or analysed in this study.</p>
</sec>
<sec id="s20014">
<title>Disclaimer</title>
<p>The views and opinions expressed in this article are those of the authors and do not necessarily reflect the official policy or position of any affiliated agency of the authors.</p>
</sec>
</ack>
<ref-list id="references">
<title>References</title>
<ref id="CIT0001"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Abera Abaerei</surname>, <given-names>A</given-names></string-name>., <string-name><surname>Ncayiyana</surname>, <given-names>J</given-names></string-name>. &#x0026; <string-name><surname>Levin</surname>, <given-names>J</given-names></string-name></person-group>., <year>2017</year>, &#x2018;<article-title>Health-care utilization and associated factors in Gauteng Province, South Africa</article-title>&#x2019;, <source><italic>Global Health Action</italic></source> <volume>10</volume>(<issue>1</issue>), <fpage>1305765</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1080/16549716.2017.1305765">https://doi.org/10.1080/16549716.2017.1305765</ext-link></comment></mixed-citation></ref>
<ref id="CIT0002"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Ackerman</surname>, <given-names>I.N</given-names></string-name>. &#x0026; <string-name><surname>Bennell</surname>, <given-names>K.L</given-names></string-name></person-group>., <year>2004</year>, &#x2018;<article-title>Does pre-operative physiotherapy improve outcomes from lower limb joint replacement surgery? A systematic review</article-title>&#x2019;, <source><italic>Australian Journal of Physiotherapy</italic></source> <volume>50</volume>(<issue>1</issue>), <fpage>25</fpage>&#x2013;<lpage>30</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/s0004-9514(14)60245-2">https://doi.org/10.1016/s0004-9514(14)60245-2</ext-link></comment></mixed-citation></ref>
<ref id="CIT0003"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Almeida</surname>, <given-names>G.J</given-names></string-name>., <string-name><surname>Khoja</surname>, <given-names>S.S</given-names></string-name>. &#x0026; <string-name><surname>Zelle</surname>, <given-names>B.A</given-names></string-name></person-group>., <year>2020</year>, &#x2018;<article-title>Effect of prehabilitation in older adults undergoing total joint replacement: An overview of systematic reviews</article-title>&#x2019;, <source><italic>Current Geriatrics Reports</italic></source> <volume>9</volume>(<issue>4</issue>), <fpage>280</fpage>&#x2013;<lpage>287</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1007/s13670-020-00342-6">https://doi.org/10.1007/s13670-020-00342-6</ext-link></comment></mixed-citation></ref>
<ref id="CIT0004"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Aytekin</surname>, <given-names>E</given-names></string-name>., <string-name><surname>Sukur</surname>, <given-names>E</given-names></string-name>., <string-name><surname>Oz</surname>, <given-names>N</given-names></string-name>., <string-name><surname>Telatar</surname>, <given-names>A</given-names></string-name>., <string-name><surname>Eroglu Demir</surname>, <given-names>S</given-names></string-name>., <string-name><surname>Sayiner Caglar</surname>, <given-names>N</given-names></string-name>. <etal>et al.</etal></person-group>, <year>2019</year>, &#x2018;<article-title>The effect of a 12 week prehabilitation program on pain and function for patients undergoing total knee arthroplasty: A prospective controlled study</article-title>&#x2019;, <source><italic>Journal of Clinical Orthopaedics and Trauma</italic></source> <volume>10</volume>(<issue>2</issue>), <fpage>345</fpage>&#x2013;<lpage>349</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.jcot.2018.04.006">https://doi.org/10.1016/j.jcot.2018.04.006</ext-link></comment></mixed-citation></ref>
<ref id="CIT0005"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Barbay</surname>, <given-names>K</given-names></string-name></person-group>., <year>2009</year>, &#x2018;<article-title>Research evidence for the use of preoperative exercise in patients preparing for total hip or total knee arthroplasty</article-title>&#x2019;, <source><italic>Orthopaedic Nursing</italic></source> <volume>28</volume>(<issue>3</issue>), <fpage>127</fpage>&#x2013;<lpage>133</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1097/NOR.0b013e3181a46a09">https://doi.org/10.1097/NOR.0b013e3181a46a09</ext-link></comment></mixed-citation></ref>
<ref id="CIT0006"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Beaupre</surname>, <given-names>L.A</given-names></string-name>., <string-name><surname>Lier</surname>, <given-names>D</given-names></string-name>., <string-name><surname>Davies</surname>, <given-names>D.M</given-names></string-name>. &#x0026; <string-name><surname>Johnston</surname>, <given-names>D.B</given-names></string-name></person-group>., <year>2004</year>, &#x2018;<article-title>The effect of a preoperative exercise and education program on functional recovery, health related quality of life, and health service utilization following primary total knee arthroplasty</article-title>&#x2019;, <source><italic>Journal of Rheumatology</italic></source> <volume>31</volume>(<issue>6</issue>), <fpage>1166</fpage>&#x2013;<lpage>1173</lpage>.</mixed-citation></ref>
<ref id="CIT0007"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Biccard</surname>, <given-names>B.M</given-names></string-name>. &#x0026; <string-name><surname>Madiba</surname>, <given-names>T.E</given-names></string-name></person-group>., <year>2015</year>, &#x2018;<article-title>The South African surgical outcomes study: A 7-day prospective observational cohort study</article-title>&#x2019;, <source><italic>South African Medical Journal</italic></source> <volume>105</volume>(<issue>6</issue>), <fpage>465</fpage>&#x2013;<lpage>475</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.7196/samj.9435">https://doi.org/10.7196/samj.9435</ext-link></comment></mixed-citation></ref>
<ref id="CIT0008"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Brennan-Olsen</surname>, <given-names>S.L</given-names></string-name>., <string-name><surname>Cook</surname>, <given-names>S</given-names></string-name>., <string-name><surname>Leech</surname>, <given-names>M.T</given-names></string-name>., <string-name><surname>Bowe</surname>, <given-names>S.J</given-names></string-name>., <string-name><surname>Kowal</surname>, <given-names>P</given-names></string-name>., <string-name><surname>Naidoo</surname>, <given-names>N</given-names></string-name>. <etal>et al.</etal></person-group>, <year>2017</year>, &#x2018;<article-title>Prevalence of arthritis according to age, sex and socioeconomic status in six low and middle income countries: analysis of data from the World Health Organization study on global AGEing and adult health (SAGE) Wave 1</article-title>&#x2019;, <source><italic>BMC Musculoskeletal Disorders</italic></source> <volume>18</volume>(<issue>1</issue>), <fpage>271</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1186/s12891-017-1624-z">https://doi.org/10.1186/s12891-017-1624-z</ext-link></comment></mixed-citation></ref>
<ref id="CIT0009"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Brown</surname>, <given-names>K</given-names></string-name>., <string-name><surname>Loprinzi</surname>, <given-names>P.D</given-names></string-name>., <string-name><surname>Brosky</surname>, <given-names>J.A</given-names></string-name>. &#x0026; <string-name><surname>Topp</surname>, <given-names>R</given-names></string-name></person-group>., <year>2014</year>, &#x2018;<article-title>Prehabilitation influences exercise-related psychological constructs such as self-efficacy and outcome expectations to exercise</article-title>&#x2019;, <source><italic>The Journal of Strength and Conditioning Research</italic></source> <volume>28</volume>(<issue>1</issue>), <fpage>201</fpage>&#x2013;<lpage>209</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1519/JSC.0b013e318295614a">https://doi.org/10.1519/JSC.0b013e318295614a</ext-link></comment></mixed-citation></ref>
<ref id="CIT0010"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Brown</surname>, <given-names>K</given-names></string-name>., <string-name><surname>Topp</surname>, <given-names>R</given-names></string-name>., <string-name><surname>Brosky</surname>, <given-names>J.A</given-names></string-name>. &#x0026; <string-name><surname>Lajoie</surname>, <given-names>A.S</given-names></string-name></person-group>., <year>2012</year>, &#x2018;<article-title>Prehabilitation and quality of life three months after total knee arthroplasty: A pilot study</article-title>&#x2019;, <source><italic>Perceptual and Motor Skills</italic></source> <volume>115</volume>(<issue>3</issue>), <fpage>765</fpage>&#x2013;<lpage>774</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.2466/15.06.10.Pms.115.6.765-774">https://doi.org/10.2466/15.06.10.Pms.115.6.765-774</ext-link></comment></mixed-citation></ref>
<ref id="CIT0011"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Calatayud</surname>, <given-names>J</given-names></string-name>., <string-name><surname>Casa&#x00F1;a</surname>, <given-names>J</given-names></string-name>., <string-name><surname>Ezzatvar</surname>, <given-names>Y</given-names></string-name>., <string-name><surname>Jakobsen</surname>, <given-names>M.D</given-names></string-name>., <string-name><surname>Sundstrup</surname>, <given-names>E</given-names></string-name>. &#x0026; <string-name><surname>Andersen</surname>, <given-names>L.L</given-names></string-name></person-group>., <year>2017</year>, &#x2018;<article-title>High-intensity preoperative training improves physical and functional recovery in the early post-operative periods after total knee arthroplasty: A randomized controlled trial</article-title>&#x2019;, <source><italic>Knee Surgery, Sports Traumatology, Arthroscopy</italic></source> <volume>25</volume>(<issue>9</issue>), <fpage>2864</fpage>&#x2013;<lpage>2872</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1007/s00167-016-3985-5">https://doi.org/10.1007/s00167-016-3985-5</ext-link></comment></mixed-citation></ref>
<ref id="CIT0012"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Cavill</surname>, <given-names>S</given-names></string-name>., <string-name><surname>McKenzie</surname>, <given-names>K</given-names></string-name>., <string-name><surname>Munro</surname>, <given-names>A</given-names></string-name>., <string-name><surname>McKeever</surname>, <given-names>J</given-names></string-name>., <string-name><surname>Whelan</surname>, <given-names>L</given-names></string-name>., <string-name><surname>Biggs</surname>, <given-names>L</given-names></string-name>. <etal>et al.</etal></person-group>, <year>2016</year>, &#x2018;<article-title>The effect of prehabilitation on the range of motion and functional outcomes in patients following the total knee or hip arthroplasty: A pilot randomized trial</article-title>&#x2019;, <source><italic>Physiotherapy Theory and Practice</italic></source> <volume>32</volume>(<issue>4</issue>), <fpage>1</fpage>&#x2013;<lpage>9</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3109/09593985.2016.1138174">https://doi.org/10.3109/09593985.2016.1138174</ext-link></comment></mixed-citation></ref>
<ref id="CIT0013"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Chen</surname>, <given-names>H</given-names></string-name>., <string-name><surname>Li</surname>, <given-names>S</given-names></string-name>., <string-name><surname>Ruan</surname>, <given-names>T</given-names></string-name>., <string-name><surname>Liu</surname>, <given-names>L</given-names></string-name>. &#x0026; <string-name><surname>Fang</surname>, <given-names>L</given-names></string-name></person-group>., <year>2018</year>, &#x2018;<article-title>Is it necessary to perform prehabilitation exercise for patients undergoing total knee arthroplasty: Meta-analysis of randomized controlled trials</article-title>&#x2019;, <source><italic>The Physician and Sportsmedicine</italic></source> <volume>46</volume>(<issue>1</issue>), <fpage>36</fpage>&#x2013;<lpage>43</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1080/00913847.2018.1403274">https://doi.org/10.1080/00913847.2018.1403274</ext-link></comment></mixed-citation></ref>
<ref id="CIT0014"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Clode</surname>, <given-names>N.J</given-names></string-name>., <string-name><surname>Perry</surname>, <given-names>M.A</given-names></string-name>. &#x0026; <string-name><surname>Wulff</surname>, <given-names>L</given-names></string-name></person-group>., <year>2018</year>, &#x2018;<article-title>Does physiotherapy prehabilitation improve pre-surgical outcomes and influence patient expectations prior to knee and hip joint arthroplasty?</article-title>&#x2019;, <source><italic>International Journal of Orthopaedic and Trauma Nursing</italic></source> <volume>30</volume>, <fpage>14</fpage>&#x2013;<lpage>19</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.ijotn.2018.05.004">https://doi.org/10.1016/j.ijotn.2018.05.004</ext-link></comment></mixed-citation></ref>
<ref id="CIT0015"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Coudeyre</surname>, <given-names>E</given-names></string-name>., <string-name><surname>Jardin</surname>, <given-names>C</given-names></string-name>., <string-name><surname>Givron</surname>, <given-names>P</given-names></string-name>., <string-name><surname>Ribinik</surname>, <given-names>P</given-names></string-name>., <string-name><surname>Revel</surname>, <given-names>M</given-names></string-name>. &#x0026; <string-name><surname>Rannou</surname>, <given-names>F</given-names></string-name></person-group>., <year>2007</year>, &#x2018;<article-title>Could preoperative rehabilitation modify postoperative outcomes after total hip and knee arthroplasty? Elaboration of French clinical practice guidelines</article-title>&#x2019;, <source><italic>Annales de R&#x00E9;adaptation et de M&#x00E9;decine Physique</italic></source> <volume>50</volume>(<issue>3</issue>), <fpage>189</fpage>&#x2013;<lpage>197</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.annrmp.2007.02.002">https://doi.org/10.1016/j.annrmp.2007.02.002</ext-link></comment></mixed-citation></ref>
<ref id="CIT0016"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>D&#x2019;Lima</surname>, <given-names>D.D</given-names></string-name>., <string-name><surname>Colwell</surname>, <given-names>C.W.</given-names> <suffix>Jr.</suffix></string-name>, <string-name><surname>Morris</surname>, <given-names>B.A</given-names></string-name>., <string-name><surname>Hardwick</surname>, <given-names>M.E</given-names></string-name>. &#x0026; <string-name><surname>Kozin</surname>, <given-names>F</given-names></string-name></person-group>., <year>1996</year>, &#x2018;<article-title>The effect of preoperative exercise on total knee replacement outcomes</article-title>&#x2019;, <source><italic>Clinical Orthopaedics and Related Research</italic></source> <volume>326</volume>, <fpage>174</fpage>&#x2013;<lpage>182</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1097/00003086-199605000-00020">https://doi.org/10.1097/00003086-199605000-00020</ext-link></comment></mixed-citation></ref>
<ref id="CIT0017"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Denduluri</surname>, <given-names>S.K</given-names></string-name>., <string-name><surname>Huddleston</surname>, <given-names>J.I.</given-names> <prefix>3rd</prefix></string-name>, &#x0026; <string-name><surname>Amanatullah</surname>, <given-names>D.F</given-names></string-name></person-group>., <year>2020</year>, &#x2018;<article-title>Preoperative exercise participation reflects patient engagement and predicts earlier patient discharge and less gait aid dependence after total joint arthroplasty</article-title>&#x2019;, <source><italic>Orthopedics</italic></source> <volume>43</volume>(<issue>5</issue>), <fpage>e364</fpage>&#x2013;<lpage>e368</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3928/01477447-20200619-04">https://doi.org/10.3928/01477447-20200619-04</ext-link></comment></mixed-citation></ref>
<ref id="CIT0018"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Desmeules</surname>, <given-names>F</given-names></string-name>., <string-name><surname>Hall</surname>, <given-names>J</given-names></string-name>. &#x0026; <string-name><surname>Woodhouse</surname>, <given-names>L.J</given-names></string-name></person-group>., <year>2013</year>, &#x2018;<article-title>Prehabilitation improves physical function of individuals with severe disability from hip or knee osteoarthritis</article-title>&#x2019;, <source><italic>Physiotherapy Canada</italic></source> <volume>65</volume>(<issue>2</issue>), <fpage>116</fpage>&#x2013;<lpage>124</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3138/ptc.2011-60">https://doi.org/10.3138/ptc.2011-60</ext-link></comment></mixed-citation></ref>
<ref id="CIT0019"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Doiron-Cadrin</surname>, <given-names>P</given-names></string-name>., <string-name><surname>Kairy</surname>, <given-names>D</given-names></string-name>., <string-name><surname>Vendittoli</surname>, <given-names>P.A</given-names></string-name>., <string-name><surname>Lowry</surname>, <given-names>V</given-names></string-name>., <string-name><surname>Poitras</surname>, <given-names>S</given-names></string-name>. &#x0026; <string-name><surname>Desmeules</surname>, <given-names>F</given-names></string-name></person-group>., <year>2020</year>, &#x2018;<article-title>Feasibility and preliminary effects of a tele-prehabilitation program and an in-person prehablitation program compared to usual care for total hip or knee arthroplasty candidates: A pilot randomized controlled trial</article-title>&#x2019;, <source><italic>Disability and Rehabilitation</italic></source> <volume>42</volume>(<issue>7</issue>), <fpage>989</fpage>&#x2013;<lpage>998</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1080/09638288.2018.1515992">https://doi.org/10.1080/09638288.2018.1515992</ext-link></comment></mixed-citation></ref>
<ref id="CIT0020"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Dom&#x00ED;nguez-Navarro</surname>, <given-names>F</given-names></string-name>., <string-name><surname>Igual-Camacho</surname>, <given-names>C</given-names></string-name>., <string-name><surname>Silvestre-Mu&#x00F1;oz</surname>, <given-names>A</given-names></string-name>., <string-name><surname>Roig-Casas&#x00FA;s</surname>, <given-names>S</given-names></string-name>. &#x0026; <string-name><surname>Blasco</surname>, <given-names>J.M</given-names></string-name></person-group>., <year>2018</year>, &#x2018;<article-title>Effects of balance and proprioceptive training on total hip and knee replacement rehabilitation: A systematic review and meta-analysis</article-title>&#x2019;, <source><italic>Gait &#x0026; Posture</italic></source> <volume>62</volume>, <fpage>68</fpage>&#x2013;<lpage>74</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.gaitpost.2018.03.003">https://doi.org/10.1016/j.gaitpost.2018.03.003</ext-link></comment></mixed-citation></ref>
<ref id="CIT0021"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Duman</surname>, <given-names>I</given-names></string-name>., <string-name><surname>Taskaynatan</surname>, <given-names>M.A</given-names></string-name>., <string-name><surname>Mohur</surname>, <given-names>H</given-names></string-name>. &#x0026; <string-name><surname>Tan</surname>, <given-names>A.K</given-names></string-name></person-group>., <year>2012</year>, &#x2018;<article-title>Assessment of the impact of proprioceptive exercises on balance and proprioception in patients with advanced knee osteoarthritis</article-title>&#x2019;, <source><italic>Rheumatology International</italic></source> <volume>32</volume>(<issue>12</issue>), <fpage>3793</fpage>&#x2013;<lpage>3798</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1007/s00296-011-2272-5">https://doi.org/10.1007/s00296-011-2272-5</ext-link></comment></mixed-citation></ref>
<ref id="CIT0022"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Dunn</surname>, <given-names>R</given-names></string-name></person-group>., <year>2012</year>, &#x2018;<article-title>Musculoskeletal burden of disease: Do we have any idea?</article-title>&#x2019;, <source><italic>SA Orthopaedic Journal</italic></source> <volume>11</volume>(<issue>2</issue>), <fpage>20</fpage>&#x2013;<lpage>22</lpage>, <comment>viewed n.d., from <ext-link ext-link-type="uri" xlink:href="http://www.scielo.org.za/pdf/saoj/v11n2/03.pdf">http://www.scielo.org.za/pdf/saoj/v11n2/03.pdf</ext-link></comment></mixed-citation></ref>
<ref id="CIT0023"><mixed-citation publication-type="book"><person-group person-group-type="author"><string-name><surname>Ehrlich</surname>, <given-names>S.G</given-names></string-name></person-group>., <year>2019</year>, <source><italic>Total knee arthroplasty prehabilitation: Clinical decisions related to Bony malalignment, neurologic complexities, and getting to know a patient</italic></source>, <publisher-name>University of Iowa</publisher-name>, <publisher-loc>Iowa City, IA</publisher-loc>.</mixed-citation></ref>
<ref id="CIT0024"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Fernandes</surname>, <given-names>L</given-names></string-name>., <string-name><surname>Roos</surname>, <given-names>E.M</given-names></string-name>., <string-name><surname>Overgaard</surname>, <given-names>S</given-names></string-name>., <string-name><surname>Villadsen</surname>, <given-names>A</given-names></string-name>. &#x0026; <string-name><surname>S&#x00F8;gaard</surname>, <given-names>R</given-names></string-name></person-group>., <year>2017</year>, &#x2018;<article-title>Supervised neuromuscular exercise prior to hip and knee replacement: 12-month clinical effect and cost-utility analysis alongside a randomised controlled trial</article-title>&#x2019;, <source><italic>BMC Musculoskeletal Disorders</italic></source> <volume>18</volume>(<issue>1</issue>), <fpage>5</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1186/s12891-016-1369-0">https://doi.org/10.1186/s12891-016-1369-0</ext-link></comment></mixed-citation></ref>
<ref id="CIT0025"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Gill</surname>, <given-names>S.D</given-names></string-name>. &#x0026; <string-name><surname>McBurney</surname>, <given-names>H</given-names></string-name></person-group>., <year>2013</year>, &#x2018;<article-title>Does exercise reduce pain and improve physical function before hip or knee replacement surgery? A systematic review and meta-analysis of randomized controlled trials</article-title>&#x2019;, <source><italic>Archives of Physical Medicine and Rehabilitation</italic></source> <volume>94</volume>(<issue>1</issue>), <fpage>164</fpage>&#x2013;<lpage>176</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.apmr.2012.08.211">https://doi.org/10.1016/j.apmr.2012.08.211</ext-link></comment></mixed-citation></ref>
<ref id="CIT0026"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Gill</surname>, <given-names>S.D</given-names></string-name>., <string-name><surname>McBurney</surname>, <given-names>H</given-names></string-name>. &#x0026; <string-name><surname>Schulz</surname>, <given-names>D.L</given-names></string-name></person-group>., <year>2009</year>, &#x2018;<article-title>Land-based versus pool-based exercise for people awaiting joint replacement surgery of the hip or knee: Results of a randomized controlled trial</article-title>&#x2019;, <source><italic>Archives of Physical Medicine and Rehabilitation</italic></source> <volume>90</volume>(<issue>3</issue>), <fpage>388</fpage>&#x2013;<lpage>394</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.apmr.2008.09.561">https://doi.org/10.1016/j.apmr.2008.09.561</ext-link></comment></mixed-citation></ref>
<ref id="CIT0027"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Golightly</surname>, <given-names>Y.M</given-names></string-name>., <string-name><surname>Hannan</surname>, <given-names>M.T</given-names></string-name>., <string-name><surname>Dufour</surname>, <given-names>A.B</given-names></string-name>., <string-name><surname>Renner</surname>, <given-names>J.B</given-names></string-name>. &#x0026; <string-name><surname>Jordan</surname>, <given-names>J.M</given-names></string-name></person-group>., <year>2015</year>, &#x2018;<article-title>Factors associated with hallux valgus in a community-based cross-sectional study of adults with and without osteoarthritis</article-title>&#x2019;, <source><italic>Arthritis Care &#x0026; Research</italic></source> <volume>67</volume>(<issue>6</issue>), <fpage>791</fpage>&#x2013;<lpage>798</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1002/acr.22517">https://doi.org/10.1002/acr.22517</ext-link></comment></mixed-citation></ref>
<ref id="CIT0028"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>He</surname>, <given-names>Y</given-names></string-name>., <string-name><surname>Li</surname>, <given-names>Z</given-names></string-name>., <string-name><surname>Alexander</surname>, <given-names>P.G</given-names></string-name>., <string-name><surname>Ocasio-Nieves</surname>, <given-names>B.D</given-names></string-name>., <string-name><surname>Yocum</surname>, <given-names>L</given-names></string-name>., <string-name><surname>Lin</surname>, <given-names>H</given-names></string-name>. <etal>et al.</etal></person-group>, <year>2020</year>, &#x2018;<article-title>Pathogenesis of osteoarthritis: Risk factors, regulatory pathways in chondrocytes, and experimental models</article-title>&#x2019;, <source><italic>Biology</italic></source> <volume>9</volume>(<issue>8</issue>), <fpage>194</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3390/biology9080194">https://doi.org/10.3390/biology9080194</ext-link></comment></mixed-citation></ref>
<ref id="CIT0029"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Huber</surname>, <given-names>E.O</given-names></string-name>., <string-name><surname>Roos</surname>, <given-names>E.M</given-names></string-name>., <string-name><surname>Meichtry</surname>, <given-names>A</given-names></string-name>., <string-name><surname>De Bie</surname>, <given-names>R.A</given-names></string-name>. &#x0026; <string-name><surname>Bischoff-Ferrari</surname>, <given-names>H.A</given-names></string-name></person-group>., <year>2015</year>, &#x2018;<article-title>Effect of preoperative neuromuscular training (NEMEX-TJR) on functional outcome after total knee replacement: An assessor-blinded randomized controlled trial</article-title>&#x2019;, <source><italic>BMC Musculoskelet Disorders</italic></source> <volume>16</volume>(<issue>1</issue>), <fpage>101</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1186/s12891-015-0556-8">https://doi.org/10.1186/s12891-015-0556-8</ext-link></comment></mixed-citation></ref>
<ref id="CIT0030"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>James</surname>, <given-names>S</given-names></string-name>. &#x0026; <string-name><surname>Miza</surname>, <given-names>T.M</given-names></string-name></person-group>., <year>2015</year>, &#x2018;<article-title>Perceptions of professional nurses regarding introduction of the Batho Pele principles in State hospitals</article-title>&#x2019;, <source><italic>Curationis</italic></source> <volume>38</volume>(<issue>1</issue>), <fpage>a1128</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.4102/curationis.v38i1.1128">https://doi.org/10.4102/curationis.v38i1.1128</ext-link></comment></mixed-citation></ref>
<ref id="CIT0031"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Kavalieratos</surname>, <given-names>T</given-names></string-name>., <string-name><surname>Nortje</surname>, <given-names>M</given-names></string-name>. &#x0026; <string-name><surname>Dunn</surname>, <given-names>R.N</given-names></string-name></person-group>., <year>2017</year>, &#x2018;<article-title>Hip and knee arthroplasty waiting list &#x2013; How accurate and fair?</article-title>&#x2019;, <source><italic>South African Medical Journal</italic></source> <volume>107</volume>(<issue>4</issue>), <fpage>323</fpage>&#x2013;<lpage>326</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.7196/SAMJ.2017.v107i4.12145">https://doi.org/10.7196/SAMJ.2017.v107i4.12145</ext-link></comment></mixed-citation></ref>
<ref id="CIT0032"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Kim</surname>, <given-names>S</given-names></string-name>., <string-name><surname>Hsu</surname>, <given-names>F.-C</given-names></string-name>., <string-name><surname>Groban</surname>, <given-names>L</given-names></string-name>., <string-name><surname>Williamson</surname>, <given-names>J</given-names></string-name>. &#x0026; <string-name><surname>Messier</surname>, <given-names>S</given-names></string-name></person-group>., <year>2020</year>, &#x2018;<article-title>A randomized clinical trial of prehabilitation using aquatic exercise in older adults with knee osteoarthritis undergoing total knee arthroplasty</article-title>&#x2019;, <source><italic>Research Square</italic></source>, <comment>viewed n.d., from <ext-link ext-link-type="uri" xlink:href="https://www.researchsquare.com/article/rs-37189/v1">https://www.researchsquare.com/article/rs-37189/v1</ext-link></comment></mixed-citation></ref>
<ref id="CIT0033"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Kosek</surname>, <given-names>E</given-names></string-name>., <string-name><surname>Roos</surname>, <given-names>E.M</given-names></string-name>., <string-name><surname>Ageberg</surname>, <given-names>E</given-names></string-name>. &#x0026; <string-name><surname>Nilsdotter</surname>, <given-names>A</given-names></string-name></person-group>., <year>2013</year>, &#x2018;<article-title>Increased pain sensitivity but normal function of exercise induced analgesia in hip and knee osteoarthritis &#x2013; Treatment effects of neuromuscular exercise and total joint replacement</article-title>&#x2019;, <source><italic>Osteoarthritis and Cartilage</italic></source> <volume>21</volume>(<issue>9</issue>), <fpage>1299</fpage>&#x2013;<lpage>1307</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.joca.2013.06.019">https://doi.org/10.1016/j.joca.2013.06.019</ext-link></comment></mixed-citation></ref>
<ref id="CIT0034"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Kurtz</surname>, <given-names>S.M</given-names></string-name>., <string-name><surname>Lau</surname>, <given-names>E</given-names></string-name>., <string-name><surname>Ong</surname>, <given-names>K</given-names></string-name>., <string-name><surname>Zhao</surname>, <given-names>K</given-names></string-name>., <string-name><surname>Kelly</surname>, <given-names>M</given-names></string-name>. &#x0026; <string-name><surname>Bozic</surname>, <given-names>K.J</given-names></string-name></person-group>., <year>2009</year>, &#x2018;<article-title>Future young patient demand for primary and revision joint replacement: National projections from 2010 to 2030</article-title>&#x2019;, <source><italic>Clinical Orthopaedics and Related Research</italic></source> <volume>467</volume>(<issue>10</issue>), <fpage>2606</fpage>&#x2013;<lpage>2612</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1007/s11999-009-0834-6">https://doi.org/10.1007/s11999-009-0834-6</ext-link></comment></mixed-citation></ref>
<ref id="CIT0035"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Kwok</surname>, <given-names>I.H</given-names></string-name>., <string-name><surname>Paton</surname>, <given-names>B</given-names></string-name>. &#x0026; <string-name><surname>Haddad</surname>, <given-names>F.S</given-names></string-name></person-group>., <year>2015</year>, &#x2018;<article-title>Does pre-operative physiotherapy improve outcomes in primary total knee arthroplasty? &#x2013; A systematic review</article-title>&#x2019;, <source><italic>Journal of Arthroplasty</italic></source> <volume>30</volume>(<issue>9</issue>), <fpage>1657</fpage>&#x2013;<lpage>1663</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.arth.2015.04.013">https://doi.org/10.1016/j.arth.2015.04.013</ext-link></comment></mixed-citation></ref>
<ref id="CIT0036"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Learmonth</surname>, <given-names>I.D</given-names></string-name>., <string-name><surname>Young</surname>, <given-names>C</given-names></string-name>. &#x0026; <string-name><surname>Rorabeck</surname>, <given-names>C</given-names></string-name></person-group>., <year>2007</year>, &#x2018;<article-title>The operation of the century: Total hip replacement</article-title>&#x2019;, <source><italic>Lancet</italic></source> <volume>370</volume>(<issue>9597</issue>), <fpage>1508</fpage>&#x2013;<lpage>1519</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/s0140-6736(07)60457-7">https://doi.org/10.1016/s0140-6736(07)60457-7</ext-link></comment></mixed-citation></ref>
<ref id="CIT0037"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Leveille</surname>, <given-names>S.G</given-names></string-name>., <string-name><surname>Guralnik</surname>, <given-names>J.M</given-names></string-name>., <string-name><surname>Ferrucci</surname>, <given-names>L</given-names></string-name>., <string-name><surname>Hirsch</surname>, <given-names>R</given-names></string-name>., <string-name><surname>Simonsick</surname>, <given-names>E</given-names></string-name>. &#x0026; <string-name><surname>Hochberg</surname>, <given-names>M.C</given-names></string-name></person-group>., <year>1998</year>, &#x2018;<article-title>Foot pain and disability in older women</article-title>&#x2019;, <source><italic>American Journal of Epidemiology</italic></source> <volume>148</volume>(<issue>7</issue>), <fpage>657</fpage>&#x2013;<lpage>665</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1093/aje/148.7.657">https://doi.org/10.1093/aje/148.7.657</ext-link></comment></mixed-citation></ref>
<ref id="CIT0038"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Lewis</surname>, <given-names>D</given-names></string-name>., <string-name><surname>Fullard</surname>, <given-names>K</given-names></string-name>., <string-name><surname>Kolbe</surname>, <given-names>T</given-names></string-name>., <string-name><surname>Chapman</surname>, <given-names>S</given-names></string-name>., <string-name><surname>Divanoglou</surname>, <given-names>A</given-names></string-name>., <string-name><surname>Doran</surname>, <given-names>C</given-names></string-name>. <etal>et al.</etal></person-group>, <year>2020</year>, &#x2018;<article-title>Does face-to-face pre-operative joint replacement education reduce hospital costs in a regional Australian hospital? A descriptive retrospective clinical audit</article-title>&#x2019;, <source><italic>European Journal of Orthopaedic Surgery and Traumatology</italic></source> <volume>30</volume>(<issue>2</issue>), <fpage>257</fpage>&#x2013;<lpage>265</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1007/s00590-019-02548-7">https://doi.org/10.1007/s00590-019-02548-7</ext-link></comment></mixed-citation></ref>
<ref id="CIT0039"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Long</surname>, <given-names>H</given-names></string-name>., <string-name><surname>Liu</surname>, <given-names>Q</given-names></string-name>., <string-name><surname>Yin</surname>, <given-names>H</given-names></string-name>., <string-name><surname>Wang</surname>, <given-names>K</given-names></string-name>., <string-name><surname>Diao</surname>, <given-names>N</given-names></string-name>., <string-name><surname>Zhang</surname>, <given-names>Y</given-names></string-name>. <etal>et al.</etal></person-group>, <year>2022</year>, &#x2018;<article-title>Prevalence trends of site-specific osteoarthritis from 1990 to 2019: Findings from the global burden of disease study 2019</article-title>&#x2019;, <source><italic>Arthritis &#x0026; Rheumatology</italic></source> <volume>74</volume>(<issue>7</issue>), <fpage>1172</fpage>&#x2013;<lpage>1183</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1002/art.42089">https://doi.org/10.1002/art.42089</ext-link></comment></mixed-citation></ref>
<ref id="CIT0040"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Ma</surname>, <given-names>J.-X</given-names></string-name>., <string-name><surname>Zhang</surname>, <given-names>L.-K</given-names></string-name>., <string-name><surname>Kuang</surname>, <given-names>M.-J</given-names></string-name>., <string-name><surname>Zhao</surname>, <given-names>J</given-names></string-name>., <string-name><surname>Wang</surname>, <given-names>Y</given-names></string-name>., <string-name><surname>Lu</surname>, <given-names>B</given-names></string-name>. <etal>et al.</etal></person-group>, <year>2018</year>, &#x2018;<article-title>The effect of preoperative training on functional recovery in patients undergoing total knee arthroplasty: A systematic review and meta-analysis</article-title>&#x2019;, <source><italic>International Journal of Surgery</italic></source> <volume>51</volume>, <fpage>205</fpage>&#x2013;<lpage>212</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.ijsu.2018.01.015">https://doi.org/10.1016/j.ijsu.2018.01.015</ext-link></comment></mixed-citation></ref>
<ref id="CIT0041"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>McKay</surname>, <given-names>C</given-names></string-name>., <string-name><surname>Prapavessis</surname>, <given-names>H</given-names></string-name>. &#x0026; <string-name><surname>Doherty</surname>, <given-names>T</given-names></string-name></person-group>., <year>2012</year>, &#x2018;<article-title>The effect of a prehabilitation exercise program on quadriceps strength for patients undergoing total knee arthroplasty: A randomized controlled pilot study</article-title>&#x2019;, <source><italic>PM &#x0026; R: The Journal of Injury, Function, and Rehabilitation</italic></source> <volume>4</volume>(<issue>9</issue>), <fpage>647</fpage>&#x2013;<lpage>656</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.pmrj.2012.04.012">https://doi.org/10.1016/j.pmrj.2012.04.012</ext-link></comment></mixed-citation></ref>
<ref id="CIT0042"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Menz</surname>, <given-names>H.B</given-names></string-name>. &#x0026; <string-name><surname>Lord</surname>, <given-names>S.R</given-names></string-name></person-group>., <year>2001</year>, &#x2018;<article-title>The contribution of foot problems to mobility impairment and falls in community-dwelling older people</article-title>&#x2019;, <source><italic>Journal of the American Geriatrics Society</italic></source> <volume>49</volume>(<issue>12</issue>), <fpage>1651</fpage>&#x2013;<lpage>1656</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1111/j.1532-5415.2001.49275.x">https://doi.org/10.1111/j.1532-5415.2001.49275.x</ext-link></comment></mixed-citation></ref>
<ref id="CIT0043"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Moe</surname>, <given-names>R.H</given-names></string-name>. &#x0026; <string-name><surname>Dagfinrud</surname>, <given-names>H</given-names></string-name></person-group>., <year>2014</year>, &#x2018;<article-title>A neuromuscular exercise program prior to hip or knee arthroplasty does not improve recovery of function three months after surgery</article-title>&#x2019;, <source><italic>Journal of Physiotherapy</italic></source> <volume>60</volume>(<issue>1</issue>), <fpage>59</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.jphys.2013.12.009">https://doi.org/10.1016/j.jphys.2013.12.009</ext-link></comment></mixed-citation></ref>
<ref id="CIT0044"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Morris</surname>, <given-names>J.A</given-names></string-name>., <string-name><surname>Super</surname>, <given-names>J</given-names></string-name>., <string-name><surname>Huntley</surname>, <given-names>D</given-names></string-name>., <string-name><surname>Ashdown</surname>, <given-names>T</given-names></string-name>., <string-name><surname>Harland</surname>, <given-names>W</given-names></string-name>. &#x0026; <string-name><surname>Anakwe</surname>, <given-names>R</given-names></string-name></person-group>., <year>2020</year>, &#x2018;<article-title>Waiting lists for symptomatic joint arthritis are not benign: Prioritizing patients for surgery in the setting of COVID-19</article-title>&#x2019;, <source><italic>Bone &#x0026; Joint Open</italic></source> <volume>1</volume>(<issue>8</issue>), <fpage>508</fpage>&#x2013;<lpage>511</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1302/2633-1462.18.Bjo-2020-0112.R1">https://doi.org/10.1302/2633-1462.18.Bjo-2020-0112.R1</ext-link></comment></mixed-citation></ref>
<ref id="CIT0045"><mixed-citation publication-type="conference"><person-group person-group-type="author"><string-name><surname>Motsoaledi</surname>, <given-names>A</given-names></string-name></person-group>., <year>2018</year>,. &#x2018;<article-title>National Health Insurance</article-title>&#x2019;, <conf-name>presentation to the Public Health Association of South Africa (PHASA) Conference, National Department of Health</conf-name>, <conf-loc>South Africa</conf-loc>, <conf-date>12 September 2018</conf-date>, <comment>viewed 01 August 2023, from <ext-link ext-link-type="uri" xlink:href="https://phm-sa.org/wp/wp-content/uploads/2018/09/Motsoaledi-2018-NHI-Presentation-PHASA-Conference.pdf">https://phm-sa.org/wp/wp-content/uploads/2018/09/Motsoaledi-2018-NHI-Presentation-PHASA-Conference.pdf</ext-link></comment></mixed-citation></ref>
<ref id="CIT0046"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Moyer</surname>, <given-names>R</given-names></string-name>., <string-name><surname>Ikert</surname>, <given-names>K</given-names></string-name>., <string-name><surname>Long</surname>, <given-names>K</given-names></string-name>. &#x0026; <string-name><surname>Marsh</surname>, <given-names>J</given-names></string-name></person-group>., <year>2017</year>, &#x2018;<article-title>The value of preoperative exercise and education for patients undergoing total hip and knee arthroplasty: A systematic review and meta-analysis</article-title>&#x2019;, <source><italic>JBJS Reviews</italic></source> <volume>5</volume>(<issue>12</issue>), <fpage>e2</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.2106/jbjs.Rvw.17.00015">https://doi.org/10.2106/jbjs.Rvw.17.00015</ext-link></comment></mixed-citation></ref>
<ref id="CIT0047"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Neogi</surname>, <given-names>T</given-names></string-name></person-group>., <year>2013</year>, &#x2018;<article-title>The epidemiology and impact of pain in osteoarthritis</article-title>&#x2019;, <source><italic>Osteoarthritis and Cartilage</italic></source> <volume>21</volume>(<issue>9</issue>), <fpage>1145</fpage>&#x2013;<lpage>1153</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.joca.2013.03.018">https://doi.org/10.1016/j.joca.2013.03.018</ext-link></comment></mixed-citation></ref>
<ref id="CIT0048"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Page</surname>, <given-names>M.J</given-names></string-name>., <string-name><surname>McKenzie</surname>, <given-names>J.E</given-names></string-name>., <string-name><surname>Bossuyt</surname>, <given-names>P.M</given-names></string-name>., <string-name><surname>Boutron</surname>, <given-names>I</given-names></string-name>., <string-name><surname>Hoffmann</surname>, <given-names>T.C</given-names></string-name>., <string-name><surname>Mulrow</surname>, <given-names>C.D</given-names></string-name>., <etal>et al.</etal></person-group>, <year>2021</year>, &#x2018;<article-title>The PRISMA 2020 statement: An updated guideline for reporting systematic reviews</article-title>&#x2019;, <source><italic>BMJ</italic></source> <volume>372</volume>, <fpage>n71</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1136/bmj.n71">https://doi.org/10.1136/bmj.n71</ext-link></comment></mixed-citation></ref>
<ref id="CIT0049"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Peer</surname>, <given-names>M.A</given-names></string-name>., <string-name><surname>Rush</surname>, <given-names>R</given-names></string-name>., <string-name><surname>Gallacher</surname>, <given-names>P.D</given-names></string-name>. &#x0026; <string-name><surname>Gleeson</surname>, <given-names>N</given-names></string-name></person-group>., <year>2017</year>, &#x2018;<article-title>Pre-surgery exercise and post-operative physical function of people undergoing knee replacement surgery: A systematic review and meta-analysis of randomized controlled trials</article-title>&#x2019;, <source><italic>Journal of Rehabilitation Medicine</italic></source> <volume>49</volume>(<issue>4</issue>), <fpage>304</fpage>&#x2013;<lpage>315</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.2340/16501977-2210">https://doi.org/10.2340/16501977-2210</ext-link></comment></mixed-citation></ref>
<ref id="CIT0050"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Pillay-Jayaraman</surname>, <given-names>P</given-names></string-name>., <string-name><surname>Maddocks</surname>, <given-names>S</given-names></string-name>. &#x0026; <string-name><surname>Chetty</surname>, <given-names>V</given-names></string-name></person-group>., <year>2023</year>, &#x2018;<article-title>Scoping review protocol of prehabilitation interventions for primary arthroplasty</article-title>&#x2019;, <source><italic>South African Journal of Physiotherapy</italic></source> <volume>79</volume>(<issue>1</issue>), <fpage>1831</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.4102/sajp.v79i1.1831">https://doi.org/10.4102/sajp.v79i1.1831</ext-link></comment></mixed-citation></ref>
<ref id="CIT0051"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Plenge</surname>, <given-names>U</given-names></string-name>., <string-name><surname>Parker</surname>, <given-names>R</given-names></string-name>., <string-name><surname>Davids</surname>, <given-names>S</given-names></string-name>., <string-name><surname>Davies</surname>, <given-names>G.L</given-names></string-name>., <string-name><surname>Fullerton</surname>, <given-names>Z</given-names></string-name>., <string-name><surname>Gray</surname>, <given-names>L</given-names></string-name>. <etal>et al.</etal></person-group>, <year>2020</year>, &#x2018;<article-title>Quality of recovery after total hip and knee arthroplasty in South Africa: A national prospective observational cohort study</article-title>&#x2019;, <source><italic>BMC Musculoskeletal Disorders</italic></source> <volume>21</volume>(<issue>1</issue>), <fpage>721</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1186/s12891-020-03752-x">https://doi.org/10.1186/s12891-020-03752-x</ext-link></comment></mixed-citation></ref>
<ref id="CIT0052"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Rahmatika</surname>, <given-names>R</given-names></string-name>., <string-name><surname>Novriansyah</surname>, <given-names>R</given-names></string-name>. &#x0026; <string-name><surname>Indriastuti</surname>, <given-names>L</given-names></string-name></person-group>., <year>2020</year>, &#x2018;<article-title>The effects of prehabilitation exercise using resistance bands on functional performance in total knee replacement</article-title>&#x2019;, <source><italic>The Hip and Knee Journal</italic></source> <volume>1</volume>, <fpage>8</fpage>&#x2013;<lpage>18</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.46355/hipknee.v1i1.5">https://doi.org/10.46355/hipknee.v1i1.5</ext-link></comment></mixed-citation></ref>
<ref id="CIT0053"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Roddy</surname>, <given-names>E</given-names></string-name>., <string-name><surname>Zhang</surname>, <given-names>W</given-names></string-name>. &#x0026; <string-name><surname>Doherty</surname>, <given-names>M</given-names></string-name></person-group>., <year>2008</year>, &#x2018;<article-title>Prevalence and associations of hallux valgus in a primary care population</article-title>&#x2019;, <source><italic>Arthritis and Rheumatism</italic></source> <volume>59</volume>(<issue>6</issue>), <fpage>857</fpage>&#x2013;<lpage>862</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1002/art.23709">https://doi.org/10.1002/art.23709</ext-link></comment></mixed-citation></ref>
<ref id="CIT0054"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Rooks</surname>, <given-names>D</given-names></string-name>., <string-name><surname>Huang</surname>, <given-names>J</given-names></string-name>., <string-name><surname>Bierbaum</surname>, <given-names>B</given-names></string-name>., <string-name><surname>Bolus</surname>, <given-names>S</given-names></string-name>., <string-name><surname>Rubano</surname>, <given-names>J</given-names></string-name>., <string-name><surname>Connolly</surname>, <given-names>C</given-names></string-name>. <etal>et al.</etal></person-group>, <year>2006</year>, &#x2018;<article-title>Effect of preoperative exercise on measures of functional status in men and women undergoing total hip and knee arthroplasty</article-title>&#x2019;, <source><italic>Arthritis and Rheumatism</italic></source> <volume>55</volume>(<issue>5</issue>), <fpage>700</fpage>&#x2013;<lpage>708</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1002/art.22223">https://doi.org/10.1002/art.22223</ext-link></comment></mixed-citation></ref>
<ref id="CIT0055"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Saw</surname>, <given-names>M.M</given-names></string-name>., <string-name><surname>Kruger-Jakins</surname>, <given-names>T</given-names></string-name>., <string-name><surname>Edries</surname>, <given-names>N</given-names></string-name>. &#x0026; <string-name><surname>Parker</surname>, <given-names>R</given-names></string-name></person-group>., <year>2016</year>, &#x2018;<article-title>Significant improvements in pain after a six-week physiotherapist-led exercise and education intervention, in patients with osteoarthritis awaiting arthroplasty, in South Africa: A randomised controlled trial</article-title>&#x2019;, <source><italic>BMC Musculoskeletal Disorders</italic></source> <volume>17</volume>, <fpage>236</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1186/s12891-016-1088-6">https://doi.org/10.1186/s12891-016-1088-6</ext-link></comment></mixed-citation></ref>
<ref id="CIT0056"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Sekeitto</surname>, <given-names>A.R</given-names></string-name>. &#x0026; <string-name><surname>Aden</surname>, <given-names>A.A</given-names></string-name></person-group>., <year>2021</year>, &#x2018;<article-title>Costing total hip arthroplasty in a South African state tertiary hospital</article-title>&#x2019;, <source><italic>SAMJ: South African Medical Journal</italic></source> <volume>111</volume>(<issue>3</issue>), <fpage>250</fpage>&#x2013;<lpage>254</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.7196/SAMJ.2021.v111i3.14931">https://doi.org/10.7196/SAMJ.2021.v111i3.14931</ext-link></comment></mixed-citation></ref>
<ref id="CIT0057"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Shamekh</surname>, <given-names>A</given-names></string-name>., <string-name><surname>Alizadeh</surname>, <given-names>M</given-names></string-name>., <string-name><surname>Nejadghaderi</surname>, <given-names>S.A</given-names></string-name>., <string-name><surname>Sullman</surname>, <given-names>M.J.M</given-names></string-name>., <string-name><surname>Kaufman</surname>, <given-names>J.S</given-names></string-name>., <string-name><surname>Collins</surname>, <given-names>G.S</given-names></string-name>. <etal>et al.</etal></person-group>, <year>2022</year>, &#x2018;<article-title>The burden of osteoarthritis in the Middle East and North Africa region from 1990 to 2019</article-title>&#x2019;, <source><italic>Frontiers in Medicine</italic></source> <volume>9</volume>, <fpage>881391</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3389/fmed.2022.881391">https://doi.org/10.3389/fmed.2022.881391</ext-link></comment></mixed-citation></ref>
<ref id="CIT0058"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Sharif</surname>, <given-names>B</given-names></string-name>., <string-name><surname>Kopec</surname>, <given-names>J</given-names></string-name>., <string-name><surname>Bansback</surname>, <given-names>N</given-names></string-name>., <string-name><surname>Rahman</surname>, <given-names>M.M</given-names></string-name>., <string-name><surname>Flanagan</surname>, <given-names>W.M</given-names></string-name>., <string-name><surname>Wong</surname>, <given-names>H</given-names></string-name>. <etal>et al.</etal></person-group>, <year>2015</year>, &#x2018;<article-title>Projecting the direct cost burden of osteoarthritis in Canada using a microsimulation model</article-title>&#x2019;, <source><italic>Osteoarthritis and Cartilage</italic></source> <volume>23</volume>(<issue>10</issue>), <fpage>1654</fpage>&#x2013;<lpage>1663</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.joca.2015.05.029">https://doi.org/10.1016/j.joca.2015.05.029</ext-link></comment></mixed-citation></ref>
<ref id="CIT0059"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Sharma</surname>, <given-names>R</given-names></string-name>., <string-name><surname>Ardebili</surname>, <given-names>M.A</given-names></string-name>. &#x0026; <string-name><surname>Abdulla</surname>, <given-names>I.N</given-names></string-name></person-group>., <year>2019</year>, &#x2018;<article-title>Does rehabilitation before total knee arthroplasty benefit postoperative recovery? A systematic review</article-title>&#x2019;, <source><italic>Indian Journal of Orthopaedics</italic></source> <volume>53</volume>(<issue>1</issue>), <fpage>138</fpage>&#x2013;<lpage>147</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.4103/ortho.IJOrtho_643_17">https://doi.org/10.4103/ortho.IJOrtho_643_17</ext-link></comment></mixed-citation></ref>
<ref id="CIT0060"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Shichman</surname>, <given-names>I</given-names></string-name>., <string-name><surname>Roof</surname>, <given-names>M</given-names></string-name>., <string-name><surname>Askew</surname>, <given-names>N</given-names></string-name>., <string-name><surname>Nherera</surname>, <given-names>L</given-names></string-name>., <string-name><surname>Rozell</surname>, <given-names>J.C</given-names></string-name>., <string-name><surname>Seyler</surname>, <given-names>T.M</given-names></string-name>. <etal>et al.</etal></person-group>, <year>2023</year>, &#x2018;<article-title>Projections and epidemiology of primary hip and knee arthroplasty in medicare patients to 2040&#x2013;2060</article-title>&#x2019;, <source><italic>JB JS Open Access</italic></source> <volume>8</volume>(<issue>1</issue>), <fpage>e22</fpage>. <fpage>00112</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.2106/jbjs.Oa.22.00112">https://doi.org/10.2106/jbjs.Oa.22.00112</ext-link></comment></mixed-citation></ref>
<ref id="CIT0061"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Smith</surname>, <given-names>T.O</given-names></string-name>., <string-name><surname>King</surname>, <given-names>J.J</given-names></string-name>. &#x0026; <string-name><surname>Hing</surname>, <given-names>C.B</given-names></string-name></person-group>., <year>2012</year>, &#x2018;<article-title>The effectiveness of proprioceptive-based exercise for osteoarthritis of the knee: A systematic review and meta-analysis</article-title>&#x2019;, <source><italic>Rheumatology International</italic></source> <volume>32</volume>(<issue>11</issue>), <fpage>3339</fpage>&#x2013;<lpage>3351</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1007/s00296-012-2480-7">https://doi.org/10.1007/s00296-012-2480-7</ext-link></comment></mixed-citation></ref>
<ref id="CIT0062"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Soeters</surname>, <given-names>R</given-names></string-name>., <string-name><surname>White</surname>, <given-names>P.B</given-names></string-name>., <string-name><surname>Murray-Weir</surname>, <given-names>M</given-names></string-name>., <string-name><surname>Koltsov</surname>, <given-names>J.C.B</given-names></string-name>., <string-name><surname>Alexiades</surname>, <given-names>M.M</given-names></string-name>. &#x0026; <string-name><surname>Ranawat</surname>, <given-names>A.S</given-names></string-name></person-group>., <year>2018</year>, &#x2018;<article-title>Preoperative physical therapy education reduces time to meet functional milestones after total joint arthroplasty</article-title>&#x2019;, <source><italic>Clinical Orthopaedics and Related Research</italic></source> <volume>476</volume>(<issue>1</issue>), <fpage>40</fpage>&#x2013;<lpage>48</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1007/s11999.0000000000000010">https://doi.org/10.1007/s11999.0000000000000010</ext-link></comment></mixed-citation></ref>
<ref id="CIT0063"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Sunghye</surname>, <given-names>K</given-names></string-name>., <string-name><surname>Fang-Chi</surname>, <given-names>H</given-names></string-name>., <string-name><surname>Leanne</surname>, <given-names>G</given-names></string-name>., <string-name><surname>Jeff</surname>, <given-names>W</given-names></string-name>. &#x0026; <string-name><surname>Stephen</surname>, <given-names>M</given-names></string-name></person-group>., <year>2021</year>, &#x2018;<article-title>A pilot study of aquatic prehabilitation in adults with knee osteoarthritis undergoing total knee arthroplasty &#x2013; short term outcome</article-title>&#x2019;, <source><italic>BMC Musculoskeletal Disorders</italic></source> <volume>22</volume>, <fpage>a388</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.21203/rs.3.rs-37189/v1">https://doi.org/10.21203/rs.3.rs-37189/v1</ext-link></comment>. PMID: <pub-id pub-id-type="pmid">33902505</pub-id>; PMCID: <pub-id pub-id-type="pmcid">PMC8074697</pub-id>.</mixed-citation></ref>
<ref id="CIT0064"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Swank</surname>, <given-names>A.M</given-names></string-name>., <string-name><surname>Kachelman</surname>, <given-names>J.B</given-names></string-name>., <string-name><surname>Bibeau</surname>, <given-names>W</given-names></string-name>., <string-name><surname>Quesada</surname>, <given-names>P.M</given-names></string-name>., <string-name><surname>Nyland</surname>, <given-names>J</given-names></string-name>., <string-name><surname>Malkani</surname>, <given-names>A</given-names></string-name>. <etal>et al.</etal></person-group>, <year>2011</year>, &#x2018;<article-title>Prehabilitation before total knee arthroplasty increases strength and function in older adults with severe osteoarthritis</article-title>&#x2019;, <source><italic>Journal of Strength and Conditioning Research</italic></source> <volume>25</volume>(<issue>2</issue>), <fpage>318</fpage>&#x2013;<lpage>325</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1519/JSC.0b013e318202e431">https://doi.org/10.1519/JSC.0b013e318202e431</ext-link></comment></mixed-citation></ref>
<ref id="CIT0065"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Tait</surname>, <given-names>M.A</given-names></string-name>., <string-name><surname>Dredge</surname>, <given-names>C</given-names></string-name>. &#x0026; <string-name><surname>Barnes</surname>, <given-names>C.L</given-names></string-name></person-group>., <year>2015</year>, &#x2018;<article-title>Preoperative patient education for hip and knee arthroplasty: Financial benefit?</article-title>&#x2019;, <source><italic>Journal of Surgical Orthopaedic Advances</italic></source> <volume>24</volume>(<issue>4</issue>), <fpage>246</fpage>&#x2013;<lpage>251</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3113/JSOA.2015.0246">https://doi.org/10.3113/JSOA.2015.0246</ext-link></comment></mixed-citation></ref>
<ref id="CIT0066"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Topp</surname>, <given-names>R</given-names></string-name>., <string-name><surname>Swank</surname>, <given-names>A.M</given-names></string-name>., <string-name><surname>Quesada</surname>, <given-names>P.M</given-names></string-name>., <string-name><surname>Nyland</surname>, <given-names>J</given-names></string-name>. &#x0026; <string-name><surname>Malkani</surname>, <given-names>A</given-names></string-name></person-group>., <year>2009</year>, &#x2018;<article-title>The effect of prehabilitation exercise on strength and functioning after total knee arthroplasty</article-title>&#x2019;, <source><italic>PM R: The Journal of Injury, Function, and Rehabilitation</italic></source> <volume>1</volume>(<issue>8</issue>), <fpage>729</fpage>&#x2013;<lpage>735</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.pmrj.2009.06.003">https://doi.org/10.1016/j.pmrj.2009.06.003</ext-link></comment></mixed-citation></ref>
<ref id="CIT0067"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Usenbo</surname>, <given-names>A</given-names></string-name>., <string-name><surname>Kramer</surname>, <given-names>V</given-names></string-name>., <string-name><surname>Young</surname>, <given-names>T</given-names></string-name>. &#x0026; <string-name><surname>Musekiwa</surname>, <given-names>A</given-names></string-name></person-group>., <year>2015</year>, &#x2018;<article-title>Prevalence of arthritis in Africa: A systematic review and meta-analysis</article-title>&#x2019;, <source><italic>PLoS One</italic></source> <volume>10</volume>(<issue>8</issue>), <fpage>e0133858</fpage>&#x2013;<lpage>e0133858</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1371/journal.pone.0133858">https://doi.org/10.1371/journal.pone.0133858</ext-link></comment></mixed-citation></ref>
<ref id="CIT0068"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Vasta</surname>, <given-names>S</given-names></string-name>., <string-name><surname>Papalia</surname>, <given-names>R</given-names></string-name>., <string-name><surname>Torre</surname>, <given-names>G</given-names></string-name>., <string-name><surname>Vorini</surname>, <given-names>F</given-names></string-name>., <string-name><surname>Papalia</surname>, <given-names>G</given-names></string-name>., <string-name><surname>Zampogna</surname>, <given-names>B</given-names></string-name>. <etal>et al.</etal></person-group>, <year>2020</year>, &#x2018;<article-title>The influence of preoperative physical activity on postoperative outcomes of knee and hip arthroplasty surgery in the elderly: A systematic review</article-title>&#x2019;, <source><italic>Journal of Clinical Medicine</italic></source> <volume>9</volume>(<issue>4</issue>), <fpage>969</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.3390/jcm9040969">https://doi.org/10.3390/jcm9040969</ext-link></comment></mixed-citation></ref>
<ref id="CIT0069"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Villadsen</surname>, <given-names>A</given-names></string-name>., <string-name><surname>Overgaard</surname>, <given-names>S</given-names></string-name>., <string-name><surname>Holsgaard-Larsen</surname>, <given-names>A</given-names></string-name>., <string-name><surname>Christensen</surname>, <given-names>R</given-names></string-name>. &#x0026; <string-name><surname>Roos</surname>, <given-names>E.M</given-names></string-name></person-group>., <year>2014</year>, &#x2018;<article-title>Postoperative effects of neuromuscular exercise prior to hip or knee arthroplasty: A randomised controlled trial</article-title>&#x2019;, <source><italic>Annals of the Rheumatic Diseases</italic></source> <volume>73</volume>(<issue>6</issue>), <fpage>1130</fpage>&#x2013;<lpage>1137</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1136/annrheumdis-2012-203135">https://doi.org/10.1136/annrheumdis-2012-203135</ext-link></comment></mixed-citation></ref>
<ref id="CIT0070"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Wallis</surname>, <given-names>J.A</given-names></string-name>. &#x0026; <string-name><surname>Taylor</surname>, <given-names>N.F</given-names></string-name></person-group>., <year>2011</year>, &#x2018;<article-title>Pre-operative interventions (non-surgical and non-pharmacological) for patients with hip or knee osteoarthritis awaiting joint replacement surgery &#x2013; A systematic review and meta-analysis</article-title>&#x2019;, <source><italic>Osteoarthritis and Cartilage</italic></source> <volume>19</volume>(<issue>12</issue>), <fpage>1381</fpage>&#x2013;<lpage>1395</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.joca.2011.09.001">https://doi.org/10.1016/j.joca.2011.09.001</ext-link></comment></mixed-citation></ref>
<ref id="CIT0071"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Wang</surname>, <given-names>L</given-names></string-name>., <string-name><surname>Lee</surname>, <given-names>M</given-names></string-name>., <string-name><surname>Zhang</surname>, <given-names>Z</given-names></string-name>., <string-name><surname>Moodie</surname>, <given-names>J</given-names></string-name>., <string-name><surname>Cheng</surname>, <given-names>D</given-names></string-name>. &#x0026; <string-name><surname>Martin</surname>, <given-names>J</given-names></string-name></person-group>., <year>2016</year>, &#x2018;<article-title>Does preoperative rehabilitation for patients planning to undergo joint replacement surgery improve outcomes? A systematic review and meta-analysis of randomised controlled trials</article-title>&#x2019;, <source><italic>BMJ Open</italic></source> <volume>6</volume>(<issue>2</issue>), <fpage>e009857</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1136/bmjopen-2015-009857">https://doi.org/10.1136/bmjopen-2015-009857</ext-link></comment></mixed-citation></ref>
<ref id="CIT0072"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Wang</surname>, <given-names>Y</given-names></string-name>., <string-name><surname>Liu</surname>, <given-names>H</given-names></string-name>., <string-name><surname>Li</surname>, <given-names>P</given-names></string-name>., <string-name><surname>Wang</surname>, <given-names>Y.-X</given-names></string-name>. &#x0026; <string-name><surname>Xiong</surname>, <given-names>L.-X</given-names></string-name></person-group>., <year>2006</year>, &#x2018;<article-title>Isolation and identification of lactic acid bacteria producing bile salt hydrolase and study on mechnism of recucing colestrol</article-title>&#x2019;, <source><italic>Food Science</italic></source> <volume>27</volume>, <fpage>215</fpage>&#x2013;<lpage>218</lpage>.</mixed-citation></ref>
<ref id="CIT0073"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Wilder</surname>, <given-names>F.V</given-names></string-name>., <string-name><surname>Barrett</surname>, <given-names>J.P</given-names></string-name>. &#x0026; <string-name><surname>Farina</surname>, <given-names>E.J</given-names></string-name></person-group>., <year>2005</year>, &#x2018;<article-title>The association of radiographic foot osteoarthritis and radiographic osteoarthritis at other sites</article-title>&#x2019;, <source><italic>Osteoarthritis and Cartilage</italic></source> <volume>13</volume>(<issue>3</issue>), <fpage>211</fpage>&#x2013;<lpage>215</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.joca.2004.10.021">https://doi.org/10.1016/j.joca.2004.10.021</ext-link></comment></mixed-citation></ref>
<ref id="CIT0074"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Woolf</surname>, <given-names>A.D</given-names></string-name>. &#x0026; <string-name><surname>Pfleger</surname>, <given-names>B</given-names></string-name></person-group>., <year>2003</year>, &#x2018;<article-title>Burden of major musculoskeletal conditions</article-title>&#x2019;, <source><italic>Bulletin of the World Health Organization</italic></source> <volume>81</volume>(<issue>9</issue>), <fpage>646</fpage>&#x2013;<lpage>656</lpage>.</mixed-citation></ref>
<ref id="CIT0075"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Zhang</surname>, <given-names>W.-C</given-names></string-name>., &#x0026; <string-name><surname>Xiao</surname>, <given-names>D</given-names></string-name></person-group>., <year>2020</year>, &#x2018;<article-title>Efficacy of proprioceptive training on the recovery of total joint arthroplasty patients: A meta-analysis</article-title>&#x2019;, <source><italic>Journal of Orthopaedic Surgery and Research</italic></source> <volume>15</volume>(<issue>1</issue>), <fpage>505</fpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1186/s13018-020-01970-6">https://doi.org/10.1186/s13018-020-01970-6</ext-link></comment></mixed-citation></ref>
<ref id="CIT0076"><mixed-citation publication-type="journal"><person-group person-group-type="author"><string-name><surname>Zhao</surname>, <given-names>X</given-names></string-name>., <string-name><surname>Shah</surname>, <given-names>D</given-names></string-name>., <string-name><surname>Gandhi</surname>, <given-names>K</given-names></string-name>., <string-name><surname>Wei</surname>, <given-names>W</given-names></string-name>., <string-name><surname>Dwibedi</surname>, <given-names>N</given-names></string-name>., <string-name><surname>Webster</surname>, <given-names>L</given-names></string-name>. <etal>et al.</etal></person-group>, <year>2019</year>, &#x2018;<article-title>Clinical, humanistic, and economic burden of osteoarthritis among noninstitutionalized adults in the United States</article-title>&#x2019;, <source><italic>Osteoarthritis and Cartilage</italic></source> <volume>27</volume>(<issue>11</issue>), <fpage>1618</fpage>&#x2013;<lpage>1626</lpage>. <comment><ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1016/j.joca.2019.07.002">https://doi.org/10.1016/j.joca.2019.07.002</ext-link></comment></mixed-citation></ref>
</ref-list>
<fn-group>
<fn><p><bold>How to cite this article:</bold> Pillay-Jayaraman, P., Chetty, V. &#x0026; Maddocks, S., 2023, &#x2018;A scoping review of prehabilitation interventions for arthroplasty patients&#x2019;, <italic>South African Journal of Physiotherapy</italic> 79(1), a1939. <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.4102/sajp.v79i1.1939">https://doi.org/10.4102/sajp.v79i1.1939</ext-link></p></fn>
<fn><p><bold>Note:</bold> Additional supporting information may be found in the online version of this article as Online Appendix 1, 2, 3.</p></fn>
</fn-group>
</back>
</article>